Project Grant R01NS151292
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $644,965 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate phylogenetic differences in motor neuron development between mouse and human systems. The research employs high-temporal resolution single-cell expression analysis and human induced pluripotent stem cell (hiPSC)...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $150,932 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop computational and theoretical models characterizing interactions between motor cortex and dorsolateral striatum in naturalistic motor behavior. The project uses simultaneous multi-region neural recordings from mice combined...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
- The National Institute of Neurological Disorders and Stroke awarded The Rockefeller University $630,609 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate glial cell roles in preserving dendrite integrity following neuronal injury. The research explores how glial cells sense and respond to damage in neuronal dendritic structures and substructures, including dendritic spines and sensory neuron cilia. The...
- The National Institute of Neurological Disorders and Stroke awarded Texas A&M University $500,307 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cross-neuronal structural plasticity in Drosophila motor circuits. The research addresses how different neuron and synapse types undergo structural rewiring in response to neural injury, with focus on how premotor neurons, motor neurons, and muscles in...
- The National Institute of Neurological Disorders and Stroke awarded New York University $638,783 on May 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how mammalian posterior group Hox transcription factors diversify their function to pattern the spinal cord during embryonic development. Research activities span two primary aims: examination of protein domains and specific Hox amino acids in HOXC9 and HOXC13...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded Rutgers The State University of New Jersey, School of Nursing, $474,749 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular and cellular mechanisms governing functional maturation and adult subtype diversification in spinal motor neurons. The project addresses postnatal...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on January 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to study the synaptic mechanisms of dopamine-driven reinforcement learning in cortex. The research employs in vivo imaging technology, newly developed opsins and dopamine sensors, and a novel optical brain-machine interface...
- The National Institute of Neurological Disorders and Stroke awarded The University of Chicago $603,293 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize how proprioceptive sensory information is processed through projection and local neural pathways in Drosophila larvae. The research uses two technical innovations—CRASH2P microscopy for volumetric imaging of neural dynamics in intact, freely moving...
The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $639,875 on August 10, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS151292). The recipient will characterize the molecular steps that allow post-mitotic neurons to correctly integrate into neural circuits, focusing on motor neurons that target adult leg muscles in Drosophila melanogaster. The work builds on prior mapping of neuroblast stem cells, motor neuron lineages, and single-neuron morphologies. The research will deploy two tools: one combining single-cell RNA sequencing with connectome electron micrographs to predict synaptic molecular interactions, and another to visualize cell surface proteins in fixed and live tissues. These approaches will reveal how motor neurons establish specific morphologies and connections with upstream neurons and target muscles. The principles and tools developed are intended for broad applicability across developmental and neuroscience research communities. Performance occurs in New York, New York, with a period of performance from August 10, 2026, through July 31, 2031. The assistance type is Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $639.9k | 8/7/26 |