Project Grant R01NS150332
- The National Institute of Neurological Disorders and Stroke awarded a cooperative agreement of $1,038,135 to the University of Massachusetts Medical School on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop and optimize a trivalent small interfering RNA (siRNA) therapeutic targeting Huntington's disease pathogenesis. The investigative approach employs multiple simultaneously...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $653,072 to the University of California, Los Angeles on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a spatiotemporal mapping framework for Huntington's disease progression using multimodal MRI-based circuit analysis. The research integrates structural...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $614,689 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop patient-based disease-modifying therapeutic strategies for Huntington's disease by targeting FAN1, an...
- The National Institute of Neurological Disorders and Stroke awarded Janusq LLC $698,011 on September 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct in vitro toxicity assessment and in vivo efficacy testing of HV-3, a peptide-based therapy for Huntington's disease. HV-3 disrupts valosin-containing protein (VCP) and mutant huntingtin protein interactions that trigger excessive mitophagy and neuronal death in...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $388,646 on June 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate molecular mechanisms of delta-2 receptor dysfunction in neurological diseases. The research defines how disease-associated mutations perturb GLUD2 (delta-2 type ionotropic glutamate receptor) function and architecture at the molecular level using an...
- The National Institute of Neurological Disorders and Stroke (NINDS), a component of the Department of Health and Human Services National Institutes of Health, awarded Baylor College of Medicine $124,106 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant K99NS146618). The award funds research into the mechanisms of neurological manifestations in myotonic dystrophy type 1 (DM1), a progressive neuromuscular...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for development of AAV-mediated gene silencing to treat hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC), a rare, progressive leukodystrophy caused by mutations in the TUBB4A gene. The research develops an AAV9 vector...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $555,000 to Augusta University Research Institute, Inc. on May 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of a novel optogenetic assay to study intracellular transport defects in neurodevelopmental diseases. The research addresses how motor...
- The National Institute of Neurological Disorders and Stroke awarded $198,728 to The Trustees of Columbia University in the City of New York on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research quantifying relationships between behavior, neural network activity, and metabolic dysfunction in a genetic mouse model of developmental epileptic encephalopathy. The investigator will measure behavior and...
The National Institute of Neurological Disorders and Stroke awarded the University of Mississippi Medical Center $554,565 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support translational development and mechanistic characterization of a small molecule drug candidate for Huntington's disease therapy. The recipient is conducting in vitro and in vivo studies of GLYN122, a small molecule identified through in-silico fragment scanning of the mutant huntingtin polyglutamine surface. Preliminary work demonstrated GLYN122's direct binding to mutant huntingtin, reduction of mutant huntingtin levels accompanied by autophagy induction in neurons, and blood-brain barrier penetration with decreased mutant huntingtin levels in the cortex and striatum of the R6/2 mouse model, resulting in improved motor symptoms. The funded work employs two additional genetic mouse models—YAC128 and HDHQ150—to comprehensively assess GLYN122's efficacy as a prospective treatment for Huntington's disease, an inherited neurodegenerative disorder characterized by progressive motor and cognitive decline with symptom onset around age 45 and fatal debilitation within 15–18 years of onset. Work is performed in Jackson, Mississippi, with a period of performance through April 30, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $554.6k | 8/7/26 |