Project Grant R01NS148252
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts General Hospital $161,880 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of TTYH3 protein and its relationship to CLN3 Batten disease, a rare lysosomal disorder affecting approximately 1 in 100,000 live births. The research will develop tools to study TTYH3 in the context of CLN3 disease, including...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $614,689 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop patient-based disease-modifying therapeutic strategies for Huntington's disease by targeting FAN1, an...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $616,126 on August 26, 2026, to conduct in vivo genome editing research for cerebrovascular disorders under NINDS Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The award funds research defining how and when gene editing can restore cerebrovascular and white matter integrity in an ACTA2 R179H...
- The National Institutes of Health Office of the Director awarded The General Hospital Corporation (Massachusetts General Hospital) $783,750 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to conduct therapeutic discovery in neurodegeneration using bioengineered organoids and artificial intelligence-driven genomics approaches. The award funds development of multiplexed differentiation strategies to generate midbrain organoids that integrate all major brain cell...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $322,382 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating cell-specific interleukin-1 receptor 1 (IL-1R1) signaling in focal and diffuse traumatic brain injury models. The research uses genetically engineered mice with precise...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 6, 2026. The funded research quantifies folate receptor binding potential in the human choroid plexus using MRI-PET imaging. The work addresses a critical gap in understanding cerebral folate transport in autism spectrum disorder,...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $542,777 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and functionally analyze somatic mutations contributing to sporadic amyotrophic lateral sclerosis. The research combines clinical expertise in ALS genetics with expertise in somatic mutations and single-cell analysis to investigate...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $460,625 to the University of Massachusetts Medical School on June 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This exploratory research project, scheduled for completion by May 31, 2027, investigates the roles of the deubiquitylation pathway in TDP-43 (TAR DNA-binding protein 43) pathology relevant to...
- The National Institute on Aging awarded Trustees of Boston University $3.348 million on September 15, 2025, under CFDA 93.866 (Aging Research) to investigate tRNA epitranscriptome and translational dysfunction in Alzheimer's disease and related dementias. The award, R01AG095773, extends through May 31, 2030, with performance at Boston University Medical Campus in Roxbury, Massachusetts. The project examines dysregulation of tRNA modifications in degenerating brains using the PS19 P301S MAPT...
The National Institute of Neurological Disorders and Stroke awarded $551,888 to Massachusetts General Hospital on August 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the causes and consequences of tRNA ligation defects in neurodegeneration. The research examines how genomic GGC repeat expansions drive neurodegenerative diseases through polyglycine protein aggregation. The study biochemically characterized polyglycine aggregates and identified their recruitment of FAM98B, a component of the tRNA ligase complex that catalyzes tRNA biogenesis. The work demonstrated that polyglycine aggregation sequesters tRNA ligase components and impairs tRNA splicing. The investigators confirmed that tRNA ligase components are recruited to intranuclear inclusions and depleted from the nucleoplasm in tissue samples from individuals with FXTAS and NIID. Experimental depletion of FAM98B in adult mouse brains reproduced the phenotype of human GGC repeat expansion disorders, causing cerebellar neurodegeneration, gliosis, and motor coordination defects. Work is performed in Boston, Massachusetts. The period of performance runs through May 31, 2031. This is a Project Grant, the standard NIH R01 mechanism for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $551.9k | 8/19/26 |