Project Grant R01NS146728
- The National Institute of Neurological Disorders and Stroke awarded Baylor College of Medicine $100,228 on September 30, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop optimized neurostimulation patterns for seizure control in drug-resistant epilepsy. The recipient will design and validate a novel platform combining high-entropy stimulus generation and deep learning to optimize complex pulse sequences with...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $150,512 on August 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into controlling epilepsy symptoms through precisely timed inhibition and circuit editing, focused on temporal lobe epilepsy and cognitive impairments associated with seizure disorders. The research employs closed-loop...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University $614,510 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate seizure-induced myelin plasticity as a mechanism of generalized epilepsy progression. The research tests the hypothesis that seizure-induced myelination in the corpus callosum promotes cortical hypersynchrony and generalized...
- The National Institute of Neurological Disorders and Stroke, an operating division of the National Institutes of Health under the Department of Health and Human Services, awarded $646,706 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop and validate magnetic resonance elastography and arterial spin labeling as novel complementary...
- The National Institute of Neurological Disorders and Stroke awarded Baylor College of Medicine $624,825 on March 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop computational methods for characterizing electrophysiological and genomic profiles of gliomas. The award funds research integrating multi-modal data to link molecular and electrophysiological states of glioma cells and clarify mechanisms of...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Emory University $420,142 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to explore the contribution of extracellular vesicles to epileptogenesis in temporal lobe epilepsy and Dravet syndrome. The research examines how extracellular vesicles—small membranous particles...
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $565,250 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate microglial mechanisms in status epilepticus recovery. The research tests two hypotheses on how microglia facilitate seizure termination and recovery from prolonged seizures. Aim 1 investigates the role of microglial P2RY12 receptor inhibition of...
- The National Institute of Neurological Disorders and Stroke awarded Baylor College of Medicine $508,533 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on February 11, 2026, to investigate state-dependent modulation of cerebellar mossy fiber function during eyeblink conditioning tasks in mice. The research uses Neuropixels probes and semi-supervised deep learning algorithms to overcome technical limitations of conventional...
- The National Institute of Neurological Disorders and Stroke awarded Cincinnati Children's Hospital Medical Center $1.614 million on September 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on epileptogenesis mechanisms in mtoropathies and develop AAV-mediated gene therapy approaches for intractable epilepsy caused by mTOR pathway mutations. The research leverages newly developed mouse models of...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded the University of California, Davis $548,368 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing designation). The project, "Slow-Wave Sleep Enhancement to Treat Epilepsy and Its Comorbidities" (R01NS147124), addresses the hypothesis that...
The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Baylor College of Medicine $560,954 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R01NS146728). The award funds research into synaptic inhibition during spontaneous seizures in vivo, using all-optical tools to measure principal neuron depolarization and inhibitory postsynaptic potentials in awake mice with single-cell resolution. The study employs the intrahippocampal kainate mouse model of temporal lobe epilepsy to test the hypothesis that shifts in inhibitory action during seizure generation are synapse-specific rather than circuit-wide. The investigators will optimize a genetically encoded voltage indicator for reporting membrane potential responses at inhibitory synapses and combine two-photon imaging to simultaneously characterize how synaptic inhibitory inputs change when principal neurons are recruited during seizures, addressing knowledge gaps regarding bidirectional interaction between inhibition and seizure activity in chronic epilepsy. Performance occurs in Houston, Texas, with a period of performance from September 1, 2026, through July 31, 2031. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $561.0k | 8/20/26 |