This federal Project Grant award of $216,689 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to measure the effective connectivity between excitatory and inhibitory neurons in the brain during a decision-making task. The research, conducted by the President and Fellows of Harvard College (Harvard Medical School), aims to reveal the fundamental connectivity motifs and computational mechanisms that underlie decision-making processes in the cerebral cortex. The project involves using cellular-resolution optogenetics to perturb and measure the effects on neural activity patterns, as well as developing and testing computational models to elucidate the role of inhibitory neurons in mediating choice selectivity and activity timing for decision-making. The findings are expected to provide insights into how neural circuits contribute to decision-making and how these processes may be disrupted in neurological disorders and diseases.
Generated 2/25/25, 4:25 AM