Project Grant R01NS142133
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective April 1, 2026, through March 31, 2028. The research focuses on understanding the role of skull bone marrow neutrophils in delayed neurological decline (DND) following aneurysmal...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $1.31M Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion targeted for December 31, 2030. This research award supports an investigation into the role of Enhancer of Zeste Homolog 2 (EZH2), an epigenetic modifier, in cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). The project will examine how EZH2-mediated...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, with a completion date of July 31, 2027. The award supports research investigating post-ischemic protection of white matter (WM) following ischemic stroke, addressing...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Washington University a Project Grant totaling $231,264.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, with an award date of April 8, 2026, and ultimate completion date of March 31, 2031. This research project focuses on identifying and validating cerebroprotective drug targets in human stroke patients by collecting and...
- Federal Project Grant Award Summary Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) received a $616,031 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, obligated on May 5, 2026, funds research through February 28, 2031, and supports fundamental and translational neuroscience research investigating the role...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $134,684 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2026 through May 31, 2031. The grant funds the Young Brains Summer Research Program, a 10-week hands-on laboratory research training initiative designed to provide structured...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $632,144 Project Grant award dated March 17, 2026, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant supports the SLIM-SAH (Systemic Lipid Metabolism After Aneurysmal Subarachnoid Hemorrhage) research initiative, which investigates the role of lipid...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York a Project Grant of $250,328 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for the period February 6, 2026 through January 31, 2028. The research project, "Understanding Post-Transcriptional Sex Differences in Neurological Disease," investigates how RNA-binding...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Colorado-Denver a Project Grant totaling $226,112 effective August 5, 2025, through June 30, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative investigates sex-based differences in the brain macrophage response to perinatal hypoxia-ischemia (HIE), a leading cause of neonatal death and...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $451,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2025, with a completion date of April 30, 2027. The award supports scientific research investigating estrogen modulation of chondrocyte mechanotransduction via the calcium-permeant mechanosensitive channels PIEZO1 and TRPV4. The research addresses documented sex-based health...
The University of Texas Health Science Center at Houston received a $619,975 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 4, 2026, with completion targeted for March 31, 2031. This award funds research investigating the interaction of X chromosome effects and estrogen signaling in post-stroke neuroinflammation and recovery outcomes in elderly women. The research employs both in vivo models using aged wild-type mice and in vitro approaches utilizing human induced pluripotent stem cells to examine how early estrogen replacement therapy (EERT) suppresses the KDM6A gene escape from X chromosome inactivation and downstream pro-inflammatory signaling through the KDM6A-histone H3K27-interferon regulatory factor 5 pathway, with comparative analysis against late estrogen replacement therapy (LERT) effectiveness. The project aims to elucidate the mechanistic basis for sex-specific and age-related differences in stroke vulnerability and outcomes while advancing understanding of sex hormone-chromosome interactions in post-stroke inflammation. The research addresses gaps in current knowledge regarding why women experience worse stroke outcomes after menopause and provides evidence-based investigation into optimal timing and mechanisms of hormone replacement therapy as a potential neuroprotective intervention. Deliverables include experimental findings, publications, and data contributing to the broader scientific foundation for sex-specific stroke prevention and treatment strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $620.0k | 5/5/26 |