Project Grant R01NS141997
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $4,528,840 Project Grant to The Salk Institute For Biological Studies under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The three-year award beginning August 19, 2022 will fund research to functionally dissect cerebellar output circuits that orchestrate limb motor control. Specifically, the grantee will...
- This federal Project Grant award of $1,208,677.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research conducted by President and Fellows of Harvard College, doing business as Harvard Medical School, over an 8-year period from August 2025 to July 2033. The primary goal of this research is to answer the question: How do the...
- The University of Chicago received a $433,592 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund research to assess the conditions under which long-term depression (LTD) is evoked in the cerebellum of intact mice. Specifically, the researchers will investigate how ramping activity in granule cell and Purkinje cell neurons...
- This Project Grant award of $148,040, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate how the cerebellar circuit's synaptic properties may underlie precisely timed behavioral outputs. The research project, led by the University of Colorado-Denver, will leverage optical tools to measure mossy fiber and granule cell...
- This federal Project Grant award, valued at $454,385 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS), supports a research project at New York University (NYU) investigating the cerebellum's role in perceptual timing behavior. Specifically, the project aims to use electrophysiological and optogenetic techniques to examine how the lateral cerebellum contributes to the perception of time on short timescales. The project will utilize temporal bisection tasks with...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
- This federal Project Grant award of $183,751 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to develop a miniaturized ultra-widefield micro-camera array microscope (MCAM) capable of imaging a large area of the cerebellar cortex with cellular resolution in freely behaving mice. The goal is to enable recordings of cerebellar neuronal...
- This federal Project Grant award, valued at $216,689.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at measuring the effective connectivity between excitatory and inhibitory neurons in the brain to reveal the underlying connectivity motifs and computations that contribute to decision-making. The research, to be conducted by...
- The Project Grant award titled "Homeostatic Maintenance of Neocortical Excitation-Inhibition Balance by Ciliary Neuropeptidergic Signaling" was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $290,688 award will support research conducted by Brandeis University to investigate the role of primary cilia in regulating the balance of excitation...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate how the brain learns rapid, sequential motor skills. The $107,984 award to Duke University will fund experiments to test whether a 3-factor learning rule operates at cortico-basal ganglia synapses to drive the learning of sequential movements, such as...
This federal Project Grant award of $298,805 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at Duke University to investigate the role of specific inhibitory and disinhibitory circuits within the cerebellum in learning and behavior. The research aims to establish a better understanding of how inhibitory interneurons, particularly molecular layer interneurons (MLIs), influence cerebellar processing and learning in awake animals. Key activities include in vivo recordings, cell-type specific pharmacology, and in vitro brain slice experiments to evaluate the recruitment and function of MLI1 and MLI2 subtypes in modulating Purkinje cell activity and enabling cerebellar learning. This work is expected to revise current understanding of cerebellar circuit mechanisms and provide critical insights into the distinct roles of these interneuron subtypes in behavior and learning.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $298.8k | 7/31/25 |