This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to investigate the pathogenic mechanisms of inflammatory subventricular zone injury in preterm infants. The $635,386 award to Duke University, through its Office of Research Administration Division, will fund a 5-year research project to define the role of monocyte-derived IL-1β in disrupting the ependymal barrier and stem cell niche functions in the subventricular zone following intestinal perforation in preterm infants. The research aims to identify immune signatures associated with subventricular zone injury, evaluate genetic approaches to interrogate the role of monocytic IL-1β, and assess the therapeutic potential of the LXR agonist 20-hydroxycholesterol in preventing brain injury in preterm infants. This research is intended to advance the understanding of neurological complications associated with prematurity and inform the development of novel interventions.
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