This federal Project Grant award of $576,841 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to investigate the molecular mechanisms underlying how neurons navigate to their correct targets during brain development. The research aims to: 1) define how the axon guidance receptor DCC recruits and regulates the WAVE Regulatory Complex to modulate the actin cytoskeleton during axon attraction, 2) determine how the COP9 signalosome complex works with DCC to regulate transcription, and 3) elucidate the contribution of DCC's transcriptional targets to axon and dendrite targeting. This research is expected to identify new molecular components of both netrin-dependent and netrin-independent DCC signaling, which may offer insights into developmental disorders of the nervous system and therapeutic approaches to promote nerve regeneration. The project is being conducted by The Trustees of the University of Pennsylvania over the period from January 3, 2025 to December 31, 2029.
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