Project Grant R01NS138604

Award Date 4/15/25
Completion Date 2/28/30
Dollars Obligated $738K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
California, USA
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This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of novel epigenetic editing tools to treat Rett syndrome, a devastating neurodevelopmental disorder. The $698,459 award to Epitor Therapeutics, Inc. will fund the optimization of an epigenetic editor combining a compact CRISPR-based DNA targeting...
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This $398,750 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate mitochondrial dysfunction in human astrocytes with Rett syndrome-causing MECP2 mutations. The primary research objectives are to: 1) Identify common aberrations in gene expression related to mitochondrial function in human astrocytes bearing different...
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This $738,182 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research by the Beckman Research Institute of the City of Hope to develop a genetic therapy for Rett syndrome, a rare and debilitating neurodevelopmental disorder. The research aims to precisely correct over 95% of Rett syndrome-associated mutations in the MECP2 gene using a cell cycle-independent, homologous recombination-based genome editing platform. This approach seeks to restore physiologic MECP2 gene expression while avoiding the toxicity risks associated with over- or under-expression. The grant period runs from April 2025 through February 2030.

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