This $522,500 project grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of astrocytes in Rett syndrome, a neurodevelopmental disorder. The project aims to determine if correcting the altered release of specific astrocyte-secreted proteins, particularly the class 3 semaphorin SEMA3C, can ameliorate Rett syndrome phenotypes in mouse models. The research will use in vitro experiments, in vivo proximity labeling proteomics, and molecular genetic tools to explore how changes in astrocyte-neuron communication contribute to neuronal development deficits observed in Rett syndrome. The two-year project period runs from June 1, 2024 to May 31, 2026 and is being conducted by the Salk Institute for Biological Studies in La Jolla, California.
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