The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 5-year, $686,276 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Children's Hospital of Philadelphia (CHOP) to study the cellular mechanisms underlying Aicardi-Goutières syndrome (AGS), a severe neuroinflammatory disorder. The project aims to identify the key cell types in the peripheral immune system or brain vascular compartments that drive the neuropathology of AGS, in order to develop more effective treatments. CHOP is collaborating with researchers at the University of Pittsburgh, who will provide expertise in generating AGS mouse models with human mutations and analyzing their tissue pathology and gene expression. The sub-award to the University of Pittsburgh totals $44,013. This multi-institutional research effort leverages specialized expertise to elucidate the cellular basis of AGS-related brain injury and explore potential therapeutic interventions.
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