This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $596,937.00 to the University of Wisconsin System's University of Wisconsin - Madison division to investigate the role of the RNA-binding protein FMRP in regulating mitochondrial function and energy metabolism in human neuron development.
The research aims to elucidate the mechanisms by which FMRP deficiency leads to mitochondrial dysfunction and hyperexcitability in human neurons, with a focus on the FMRP target RACK1 as a key mediator of these effects. The project will comprehensively characterize the proteome and metabolome of fragile X syndrome human neurons to further understand the metabolic regulation underlying neuronal development. This work is expected to provide critical insights into the metabolic dysregulation in fragile X syndrome and other neurodevelopmental disorders, potentially supporting the development of targeted therapeutic interventions.
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