The University of Texas Southwestern Medical Center in Dallas, Texas received a $578,632 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research to investigate how neuronal activity-induced chromatin regulation mechanisms, specifically the phosphorylation of the BRG1 chromatin remodeling protein, prime enhancers and establish epigenetic memory in neurons. The research aims to determine how this BRG1 phosphorylation regulates enhancer priming through chromosome 3D structure changes mediated by the cohesin complex, as well as examine the role of BRG1 phosphorylation in cocaine-induced gene activation and priming. The award has a project period from March 1, 2025 to December 31, 2029 and supports basic science, translational, and potentially clinical research to advance the understanding of neural plasticity and neurological disorders.
Generated 3/18/25, 3:40 AM