This Project Grant award of $596,570, made by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports research to improve the sensitivity and specificity of diffusion magnetic resonance imaging (dMRI) for detecting fiber pathways and assessing tissue microstructure in the brain.
The key objectives are to: 1) develop and validate improved methods for sub-voxel fiber identification and tissue characterization; 2) determine the reproducibility of fiber-specific diffusion properties and their dependence on tissue microstructure; and 3) quantify the intersubject variability of fiber-specific diffusion properties in both animal and human subjects. This research has the potential to enhance the utility of dMRI for applications ranging from brain connectomics to stroke detection and surgical planning by improving the reliability of sub-voxel measurements of fiber properties.
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