The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $667,235 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Virginia (UVA). This 5-year grant, running from May 2024 to April 2029, supports research to identify genetic and epigenetic factors that contribute to stroke and recurrent stroke risk, particularly in underrepresented minority populations.
The project aims to leverage DNA methylation data, SNP genotype data, and clinical phenotypes from the REGARDS and VISP stroke studies to uncover novel biomarkers and social determinants of health that influence stroke recurrence. UVA is the prime recipient, with sub-awards to the University of Alabama at Birmingham for sample selection and data analysis, and to Wake Forest University Health Sciences and East Carolina University for statistical expertise and integrated omics analyses. The research seeks to enable more personalized risk assessment and targeted prevention strategies to help eliminate disparities in stroke outcomes.
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