This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to investigate the role of astrocytic volume-regulated anion channels (VRAC) in seizure generation, epileptogenesis, and associated neurological pathologies. The $608,899 award to the Regents of the University of California at Riverside, effective from December 1, 2024 to November 30, 2029, will fund research to: 1) determine how astrocytic VRAC contribute to brain tissue swelling and seizure initiation in vivo, 2) measure the involvement and therapeutic potential of astrocytic VRAC in the development of epilepsy using genetic manipulation techniques, and 3) identify the cellular mechanisms by which VRAC mediate changes in astrocyte volume regulation and neural excitability. The overarching goal is to advance the understanding of cell volume regulation, glutamate release, and glial-neuronal interactions, with the potential to identify novel targets for treating seizure disorders, excitotoxicity, and epilepsy.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $608.9k | 11/22/24 |