This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), will support research by the University of Texas Southwestern Medical Center to analyze ascending spinal pain circuits. The $453,104 grant, awarded on February 1, 2025, will fund experiments to determine the combinatorial and pathophysiological roles of two subtypes of spinal projection neurons in chronic pain states. Additionally, the research will examine the physiological and circuit mechanisms underlying the modulation of chronic pain by the TACR1 and GPR83 neuropeptide receptor signaling pathways. This work aims to provide insights into the cellular and circuit mechanisms driving increased nociception in chronic pain and potentially identify novel therapeutic targets.
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