This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $555,499.00 to Stanford University to develop novel, non-invasive behavioral biomarkers for predicting chronic seizures and mortality in mouse models of epilepsy. The research aims to leverage Artificial Intelligence-assisted 3D video analysis and a technique called Motion Sequencing (MOSEQ) to identify hidden behavioral phenotypes associated with acquired and genetic epilepsies. Additionally, the project proposes to examine the neuronal dynamics underlying the altered expression patterns of behavioral modules in chronic epilepsy and explore the use of non-invasive focused ultrasound technology for closed-loop interventions to control seizures. The award period runs from December 1, 2024 to November 30, 2029.
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