Project Grant R01NS136349

The federal Project Grant award R01NS136349, totaling $692,292.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The primary awardee, Children's Research Institute, will conduct research to better understand the regulation of pediatric regenerative myogenesis and its implications for muscle diseases such as Duchenne muscular dystrophy (DMD). The work aims to elucidate the role of the muscle niche, including immune and stromal factors, in supporting efficient regenerative capacity of pediatric muscle. Researchers will use a combination of single-cell and spatial RNA transcriptomic analyses, along with mouse models and patient samples, to provide insights into healthy pediatric regenerative myogenesis that may have broad applicability to DMD and other early-onset degenerative muscle wasting conditions. The award period runs from April 1, 2025 to March 31, 2030.