This $541,109 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports a 5-year clinical study at the University of Washington to quantify myelin loss and recovery in ischemic stroke patients. The research aims to: 1) demonstrate the feasibility of using a novel MRI-based technique called single-point macromolecular proton fraction (MPF) mapping to assess demyelination and remyelination in stroke; 2) establish relationships between these myelin changes and clinical factors; and 3) identify associations between demyelination, remyelination, and functional recovery after stroke. The findings could provide crucial insights into the role of myelin damage and repair in stroke pathology and outcomes.
Generated 3/4/25, 7:24 AM