Project Grant R01NS134868

Award Date 8/2/24
Completion Date 7/31/29
Dollars Obligated $468K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
San Antonio, TX 78229, USA
Similar Awards
The University of Texas at San Antonio (UTSA) was awarded a $412,500 Project Grant (R21NS135514) under the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research using human cortical organoid models to uncover the cellular and molecular mechanisms by which mutations in the CHD2 gene contribute to developmental and epileptic encephalopathy, a severe form of...
This is a $538,218 federal Project Grant awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The grant supports research conducted by the University of Texas Health Science Center at Houston (UTHealth) to study the role of ERR-alpha in skeletal muscle regeneration and functional recovery for Duchenne muscular dystrophy. The project aims to advance scientific understanding and develop potential treatments for this debilitating...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,541,019 Cooperative Agreement under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Trustees of the University of Pennsylvania. The award supports a comprehensive translational and clinical research program to develop a safe and effective gene therapy treatment for the ultra-rare subset of Duchenne muscular dystrophy (DMD) patients...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $236,566.00 to the University of Alabama at Birmingham (UAB) to investigate the contribution of circadian rhythm disruption to Duchenne muscular dystrophy (DMD) disease pathology. The research aims to evaluate the role of dystrophin expression in the skeletal muscle and...
This $365,000 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of novel cellular systems for modeling DYT1 dystonia using patient-derived neurons. The key objective is to investigate the molecular pathogenesis of DYT1 dystonia, a severe hereditary movement disorder, by examining how dysregulation of the nuclear...
This $692,292 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Children's Research Institute to better understand the regulation of pediatric regenerative myogenesis and its implications for muscle disease. The project aims to investigate the interplay of immune and stromal factors in the muscle niche that...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $578,632 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The University of Texas Southwestern Medical Center. The grant, titled "Chromatin Regulation of Neuronal Activity-Induced Enhancer Priming and Epigenetic Memory", will support research to investigate how neuronal activity and chromatin regulators like BRG1 phosphorylation control...
This $195,570 federal Project Grant award was made by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research by The Regents of the University of California, San Francisco (UCSF) to investigate the role of the molecular co-chaperone DNAJC7 in preventing the aggregation of misfolded proteins associated with neurodegenerative diseases such as...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,213,665 Project Grant to the University of Texas Health Science Center at Houston (UTHealth) on September 19, 2023 to develop "Neural Recording and Simulation Tools to Address the Mesoscale Gap" under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This grant will fund research to advance understanding of the human brain by developing improved neural...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support preclinical testing of a novel gene therapy for a rare pediatric neurodegenerative disease. The $419,482 award to the University of Texas Southwestern Medical Center will fund studies to determine the minimal effective dose and post-symptomatic treatment efficacy of the...

The University of Texas Health Science Center at San Antonio (UTHSCSA) was awarded a $467,602 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to investigate the role of the protein dystrophin and the dystrophin glycoprotein complex in the maturation of inhibitory synapses in the brain, particularly in the cerebellar Purkinje cells. The research aims to determine how dystrophin deficiency, as seen in Duchenne muscular dystrophy, impacts inhibitory synapse development and function, as well as whether enhancing GABA receptor activity can rescue this synaptic maturation process. Findings from this 5-year project are expected to provide critical insights into the mechanisms underlying neurodevelopmental disorders associated with dystrophin deficiency.

Generated 7/1/25, 5:12 AM