Project Grant R01NS052738

This $1.2 million National Science Foundation project grant, awarded under the Biological Sciences program (CFDA 47.074), will fund research at the University of North Carolina at Chapel Hill from March 2023 through February 2027 toward developing a revised model of the cell cycle that captures reversible and irreversible cell cycle arrest. The principal investigator will define the molecular mechanisms governing the transition between reversible quiescence and irreversible senescence, as well...

The National Science Foundation awarded a $1,099,733 project grant to the University of Arizona under the Biological Sciences program (CFDA 47.074) to investigate neural stem cell mechanisms of resilience across the lifespan. Over a four-year period ending August 2026, the university will study how neural stem cells change at the cellular, molecular, and functional levels over time using aging rodent models. The project will specifically examine the role of female sex hormones estrogen and...

This federal Project Grant award from the Department of Health and Human Services National Institutes of Health National Cancer Institute, under the Cancer Cause and Prevention Research program (CFDA 93.393), provides $613,054 to St. Jude Children's Research Hospital Inc. to study the mechanisms by which transcription factors control different cell states in neuroblastoma, a high-risk pediatric tumor. The key objectives are to 1) interrogate how master transcription factors control the...

The Morehouse School of Medicine, Inc. will conduct research on the role of neuregulin-1 in proliferation and differentiation of brain cortical neuronal stem cells during fetal development under a $1,681,744 Project Grant from the National Science Foundation Office of Integrative Activities. The research will examine how neuregulin-1 mediates normal brain cortical development through signaling pathways involving regulators of cell cycle, neural migration, differentiation and maturation....

The University of Texas MD Anderson Cancer Center received a $460,940 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2025, through May 31, 2027. This award supports investigator-initiated research examining how glioma-associated germline risk alleles (single nucleotide polymorphisms or SNPs) impact neurodevelopmental...

This $225,306 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project between researchers at the University of Southern California (USC) and a German partner to investigate the long-term impact of early-life growth signals on adult hematopoietic (blood) stem cell function and selection. The key products and services to be delivered under this 3-year award include: 1) using stem cell transplantation and...

This $397,500 Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to study the fundamental principles linking neurodevelopmental processes to the functional organization of neural circuits. The research will utilize a new animal model, Clytia, that is capable of regenerating entire genetically ablated neural subnetworks, to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research on a novel signaling axis involving the protein connexin 43 (CX43) and its role in regulating cancer stem cells in glioblastoma, the most common and deadly form of brain cancer. The $161,000 award to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve...

The National Cancer Institute (NCI) awarded a $406,217 Project Grant (CFDA 93.395 - Cancer Treatment Research) to the University of Texas Health Science Center at Houston (UTHealth) to investigate the circadian regulation of astrocytic adenosine kinase (ADK) in the irradiated and cancer brain. The research aims to determine the impact of the circadian clock proteins BMAL1 and CLOCK on ADK expression and sleep/wake regulation following cranial radiotherapy (CRT) for brain cancers. The project...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $126,956.00 to the University of California, San Diego (UCSD) to conduct research on identifying mechanisms of adult neurogenesis in the aging brain. The key objectives of this project are to: Utilize single cell spatial transcriptomics to define the pathways of generating new neurons in aged neurogenic niches following transient, antisense oligonucleotide-mediated suppression of the PTBP1...