Project Grant R01NS051661

The National Science Foundation (NSF) awarded a 3-year, $567,284 Project Grant under the Engineering program (CFDA 47.041) to Purdue University to develop a scalable Bayesian methodology for reconstructing cardiovascular hemodynamic flow fields and cardiac structure from advanced medical imaging modalities like phase-contrast MRI, 4D flow MRI, and color Doppler echocardiography. The research aims to overcome limitations in current imaging techniques, such as inaccurate velocity flow...

The National Science Foundation (NSF) awarded a $400,000 Project Grant under the Engineering program (CFDA 47.041) to the New Jersey Institute of Technology (NJIT) to advance the understanding of how new blood vessels grow in the body. This 3-year project aims to develop data-driven models that integrate high-fidelity biophysical simulation with high-resolution imaging of real blood vessel networks undergoing growth and adaptation. The research will elucidate the fluid dynamics and biophysics...

This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...

The National Science Foundation (NSF) Office of Advanced Cyberinfrastructure awarded a 4-year, $1,000,899 Project Grant to The Leland Stanford Junior University (Stanford University) under the NSF's Computer and Information Science and Engineering (CISE) program (CFDA 47.070). The project aims to develop and publicly release a novel suite of multifidelity simulation tools for modeling vascular biomechanics and mechanobiology in the open-source SimVascular project. Specifically, the grant will...

The National Institute of Mental Health (NIMH) awarded a $156,656 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The General Hospital Corporation (doing business as Massachusetts General Hospital) to advance functional MRI (fMRI) techniques for mapping brain activity across cerebral cortical layers. The project aims to validate and benchmark a "linescan fMRI" method that can achieve higher spatial resolution than conventional laminar fMRI, enabling...

Dynocardia Inc. received a $256,000 National Science Foundation Project Grant to advance development of a novel continuous, cuffless blood pressure monitoring device. Funded through the NSF Engineering Directorate's SBIR program, the award will support Dynocardia's efforts to address motion artifacts and enable accurate, beat-to-beat blood pressure measurements in hospital intensive care and operating room settings. Accurate 24-hour blood pressure monitoring has potential to significantly...

Federal Project Grant Award Summary Brown University received a $149,190 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 1, 2025, through April 30, 2028. This award funds research investigating the dynamic properties of the blood-brain barrier (BBB) and its regulation by endothelial cell calcium signaling. The research will...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $1,583,383 to the University of Connecticut Health Center (UCHC) for a research project titled "Regulation of FLT 1 Splicing by Fibronectin and Integrin Signaling During Aging." The research aims to elucidate the molecular mechanisms by which age-related vascular changes,...

The University of Wisconsin-Milwaukee received a $298,509 project grant award from the National Science Foundation Division of Electrical, Communications and Cyber Systems under the Engineering federal grant program (CFDA 47.041). The three-year award will support research to enhance 4D-flow MRI through deep data assimilation for hemodynamic analysis of cardiovascular flows. Specifically, the University will collaborate on developing enhanced medical imaging techniques using data assimilation...

This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...