Project Grant R01MH145639
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $765,876 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced neuroimaging research on subcortical brain dynamics during human sleep. The recipient will use high-resolution 7-Tesla functional magnetic resonance imaging and simultaneous electroencephalography with a novel ultra-high-field compatible net to map circuit activity in the...
- The National Institute of Mental Health awarded The McLean Hospital Corporation $771,937 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the synaptic mechanisms underlying intermittent theta burst stimulation (ITBS) as a treatment for major depressive disorder. The research examines whether ITBS, an FDA-cleared patterned form of transcranial magnetic stimulation delivered clinically to the dorsolateral prefrontal cortex, works by enhancing...
- The National Institute of Mental Health awarded The McLean Hospital Corporation $179,096 on June 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive mechanisms underlying negative retrieval bias in major depressive disorder. The recipient will conduct research to distinguish between two competing mechanisms that may explain how depression disrupts emotional memory: increased familiarity (depression strengthens evidence for all negative...
- The National Institute of Mental Health awarded Massachusetts General Hospital $453,750 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to develop a closed-loop system for assessing target network engagement using concurrent transcranial magnetic stimulation and functional MRI. The recipient is developing a flexible radiofrequency coil array (the RF Cap) that enables functional MRI acquisition simultaneously with transcranial magnetic stimulation in a...
- The U.S. Defense Health Agency has awarded a $1,602,424.00 Project Grant to The Mclean Hospital Corporation Research Management Division, doing business as Mclean Hospital, for the project "APOE AND LIPID MECHANISMS RELEVANT TO COGNITIVE DYSFUNCTION IN PARKINSON'S DISEASE". The award, which runs from Sep 1, 2023 to Aug 31, 2027, is funded through the Military Medical Research and Development program (CFDA 12.420). The goal of this research is to investigate medical solutions for the...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $197,614 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop electroencephalographic biomarkers for the diagnosis and monitoring of catatonia. The award funds a K23 mentored patient-oriented research career development grant led by Principal Investigator James Luccarelli, MD, DPhil. The research uses detailed clinical phenotyping and machine...
- The National Institute of Mental Health awarded Brigham & Women's Hospital Inc. $863,825 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a double-blind, confirmatory efficacy trial comparing imaging-based targeting versus scalp-targeted accelerated transcranial magnetic stimulation (ATMS) for treatment-resistant major depressive disorder. The trial will enroll 120 participants to test whether imaging-targeted ATMS, using Stanford Accelerated...
- The National Institute of Mental Health awarded Boston Children's Hospital $153,560 on January 7, 2027, under the Mental Health Research Grants program (CFDA 93.242) to conduct a postdoctoral fellowship examining the relationship between sleep physiology, myelin content, and depressive symptoms in young people ages 9–26 years. The research leverages data from two ongoing R01 studies to investigate two specific aims: understanding the relationship between sleep EEG signatures (spindles and slow...
- The Defense Health Agency awarded a $1,395,504.00 Project Grant to The Mclean Hospital Corporation Research Management Division, doing business as Mclean Hospital, for the project "APOE AND LIPID MECHANISMS RELEVANT TO COGNITIVE DYSFUNCTION IN PARKINSON'S DISEASE". The award period runs from September 1, 2023 to August 31, 2027 under the Military Medical Research and Development (CFDA 12.420) federal grant program. Mclean Hospital, a non-profit psychiatric teaching hospital...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $364,648 on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242, Assistance Listing K01MH137513) to investigate deficient memory replay as a potentially treatable mechanism of impaired sleep-dependent memory consolidation in schizophrenia. Over the five-year award period (through August 31, 2030), the recipient will use electroencephalography data from...
The National Institute of Mental Health awarded The McLean Hospital Corporation $819,998 on August 19, 2026, for a project grant (R01MH145639) under the Mental Health Research Grants program (CFDA 93.242) to develop a framework called Trauma Recovery via EEG and Actigraphy Tracking (TREAT) that uses portable and conventional EEG, dry EEG, and actigraphy-based sleep monitoring to identify biomarkers of written exposure therapy in post-traumatic stress disorder. The three research aims will identify clinically relevant biomarkers by comparing pre- and post-treatment EEG and sleep data; longitudinally track neurophysiological and sleep-related markers to establish the temporal trajectory of treatment effect; and build predictive models based on baseline EEG and sleep markers to support personalized treatment selection. Work is performed in Belmont, Massachusetts, through May 31, 2031. McLean Hospital is a Harvard Medical School-affiliated psychiatric teaching hospital and established NIH grantee with substantial capacity in federal neuroscience and mental health research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $820.0k | 8/20/26 |