Project Grant R01MH143905
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $364,648 on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242, Assistance Listing K01MH137513) to investigate deficient memory replay as a potentially treatable mechanism of impaired sleep-dependent memory consolidation in schizophrenia. Over the five-year award period (through August 31, 2030), the recipient will use electroencephalography data from...
- The National Institute of Mental Health awarded Massachusetts General Hospital $453,750 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to develop a closed-loop system for assessing target network engagement using concurrent transcranial magnetic stimulation and functional MRI. The recipient is developing a flexible radiofrequency coil array (the RF Cap) that enables functional MRI acquisition simultaneously with transcranial magnetic stimulation in a...
- The National Institute of Mental Health awarded Boston Children's Hospital $153,560 on January 7, 2027, under the Mental Health Research Grants program (CFDA 93.242) to conduct a postdoctoral fellowship examining the relationship between sleep physiology, myelin content, and depressive symptoms in young people ages 9–26 years. The research leverages data from two ongoing R01 studies to investigate two specific aims: understanding the relationship between sleep EEG signatures (spindles and slow...
- The National Institute of Mental Health awarded Massachusetts General Hospital $197,578 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242, K23MH144215) to investigate sleep and circadian timing irregularities as short-term risk factors for adolescent suicide through intensive longitudinal study. The research recruits 100 adolescents hospitalized for suicidal thoughts and behaviors, continuously monitoring objective sleep metrics via wrist actigraphy and collecting...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $824,404 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning models that integrate clinician-conducted suicide risk assessments with electronic health record data to improve prediction of suicidal behavior and guide precision interventions in outpatient behavioral health settings. The research leverages routine clinical...
- The National Institute of Mental Health (NIMH) awarded a $156,656 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The General Hospital Corporation (doing business as Massachusetts General Hospital) to advance functional MRI (fMRI) techniques for mapping brain activity across cerebral cortical layers. The project aims to validate and benchmark a "linescan fMRI" method that can achieve higher spatial resolution than conventional laminar fMRI, enabling...
- The National Institute of Mental Health awarded The McLean Hospital Corporation $819,998 on August 19, 2026, for a project grant (R01MH145639) under the Mental Health Research Grants program (CFDA 93.242) to develop a framework called Trauma Recovery via EEG and Actigraphy Tracking (TREAT) that uses portable and conventional EEG, dry EEG, and actigraphy-based sleep monitoring to identify biomarkers of written exposure therapy in post-traumatic stress disorder. The three research aims will...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $790,560 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026. The award funds development of advanced artificial intelligence models to predict differential antidepressant treatment responses by integrating electronic health records and genomic data. Aim 1 involves building a large language model-based, human-in-the-loop active learning framework to...
- The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $197,614 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop electroencephalographic biomarkers for the diagnosis and monitoring of catatonia. The award funds a K23 mentored patient-oriented research career development grant led by Principal Investigator James Luccarelli, MD, DPhil. The research uses detailed clinical phenotyping and machine...
The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $765,876 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced neuroimaging research on subcortical brain dynamics during human sleep. The recipient will use high-resolution 7-Tesla functional magnetic resonance imaging and simultaneous electroencephalography with a novel ultra-high-field compatible net to map circuit activity in the brainstem, thalamus, and hypothalamus across sleep-wake states. The work will identify neural patterns underlying the descent into non-rapid eye movement sleep, arousals from sleep, and distinct electroencephalographic rhythms associated with progressively deeper sleep stages. The research will test whether these dynamics predict sleep depth and cortical sensory responses, and will determine whether sleep-associated activity patterns overlap or diverge from vigilance fluctuations and microsleeps that impair daytime cognition, using a sustained attention task. Place of performance is Charlestown, Massachusetts. The period of performance runs from August 1, 2026, through April 30, 2031. This is a Project Grant, an assistance type under which the recipient pursues investigator-initiated research aligned with program priorities. The Mental Health Research Grants program supports basic and clinical research to transform understanding and treatment of mental illnesses.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $765.9k | 7/21/26 |