Project Grant R01MH143263
- The National Institute of Mental Health awarded The Leland Stanford Junior University $722,773 under the Mental Health Research Grants program (CFDA 93.242) on July 15, 2026, to develop explainable artificial intelligence frameworks for predicting depression incidents in people with HIV. The research integrates multimodal data from 3,962 people with HIV across multiple longitudinal studies to elucidate bidirectional associations between HIV, depression, and immune dysregulation. The project...
- The National Institute of Mental Health awarded Modulo Bio, Inc. $1.479 million under the Mental Health Research Grants program (CFDA 93.242) on March 1, 2026, to develop and validate an AI-guided triculture platform modeling HIV-associated brain injury under antiretroviral therapy suppression. The platform combines induced pluripotent stem cell-derived microglia, astrocytes, and neurons to recapitulate chronic, suppressed HIV infection characteristic of the antiretroviral therapy era. The...
- The National Institute of Mental Health awarded the University of South Carolina $1,016,319 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop multimodal artificial intelligence methods for monitoring and predicting neurocognitive impairment in people with HIV. The project integrates electronic health records, genomic, survey, and imaging data from the National Institutes of Health's All of Us Research Program—a centralized repository with de-identified...
- The National Institute of Mental Health awarded Duke University $1.221 million under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to develop an AI-driven multimodal model for HIV pre-exposure prophylaxis (PrEP) candidacy assessment in women in the South, where 52% of new HIV infections occur nationally but PrEP use remains lower than in other regions and women account for a disproportionate share of new infections. The award funds development of a clinically...
- The National Institute on Drug Abuse awarded the University of Florida $1.76 million on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop SYNAPSIS-HIV-CC, a synchronized agentic prescriptive system for optimizing the HIV clinical care continuum. The system combines artificial intelligence agents, large language models, and knowledge graphs to deliver individualized healthcare recommendations across multiple HIV health outcomes: loss of care, viral...
- The National Institute on Drug Abuse, a component of the National Institutes of Health, awarded the University of Pennsylvania $500,000 on May 18, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test multimodal artificial intelligence and machine learning models that integrate structured and unstructured electronic health record data, claims, pharmacy records, genomics data, and imaging data to enhance personalized clinical decision support and address unmet...
- The National Institute of Mental Health awarded the University of California, Berkeley $759,816 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop targeted machine learning estimators for analyzing cluster randomized trials of HIV prevention strategies. The award funds methodological research addressing two critical gaps in cluster randomized trial (CRT) analysis. The first involves developing machine learning methods to minimize bias from missing data in...
- The National Institute of Mental Health awarded the University of California, San Diego $441,215 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore barriers and facilitators of HIV care and prevention service engagement among 18–45-year-old Black and Latinx sexual minority men in San Diego, San Bernardino, and Riverside Counties, California. The project investigates new intervention approaches to increase uptake and persistence of long-acting injectable...
- The National Institute of Mental Health awarded $401,760 to The Regents of the University of California, San Francisco on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242, K23 award K23MH142206). The award funds a five-year training and research project led by Jose I. Gutierrez, Jr., PhD, FNP-BC, to develop a clinical decision support prototype that integrates patient-reported preferences with electronic health record data to optimize HIV treatment delivery. The...
- The National Institute of Mental Health awarded The Johns Hopkins University $149,190 on August 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify intervention opportunities in the continuum of cognitive impairment among persons aging with HIV. The research will estimate the proportion of cognitive impairment cases among people with HIV potentially attributable to psychosocial and behavioral risk factors, prioritizing those interventions that could prevent the...
The National Institute of Mental Health awarded San Diego State University Foundation $1.137 million in a Mental Health Research Grant (CFDA 93.242) on August 1, 2026, to develop and validate multimodal artificial intelligence models predicting virologic failure among persons living with HIV. The award funds a two-year longitudinal cohort study of 200 patients at a large U.S.-based HIV clinic that integrates data from the Behavioral Engagement and Adherence Monitoring (BEAM) mobile health system with wearables and other multimodal indicators to identify modifiable factors associated with HIV treatment failure. Work includes developing knowledge graphs informed by focus groups of persons living with HIV and scientific literature to map interconnections among virologic failure predictors; designing BEAM for real-world implementation; and applying knowledge graphs and AI models to forecast virologic failure while minimizing algorithmic bias. A Community Advisory Board of persons living with HIV provides iterative feedback across all study phases to ensure models conform to AI ethical principles and remain patient-centered. Performance occurs in San Diego, California, with a completion date of April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 7/21/26 |