Project Grant R01MH142925
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of North Carolina at Chapel Hill a Project Grant of $121,887 under the Mental Health Research Grants program (CFDA 93.242) for the period November 1, 2025 through May 31, 2028. This research initiative, titled "Elucidating Estradiol Variability's Impact on Dopaminergic Reward Circuitry in Perimenopausal Anhedonia," will deliver original scientific research investigating the neurobiological...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $394,200 to the Research Foundation For Mental Hygiene, Inc. (through its New York State Psychiatric Institute division) under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2025, for a five-year project period extending through July 31, 2030. This Project Grant funds a clinical research study examining the role of the anterior hippocampus in major depressive disorder (MDD) pathogenesis....
- Federal Grant Award Summary Yale University received a $461,084 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded June 16, 2025, with completion targeted for June 15, 2027. The award funds research investigating the cellular and circuit mechanisms underlying age-dependent social behaviors, specifically examining how pro-opiomelanocortin (POMC) neurons in the hypothalamus regulate social interactions during...
- Federal Grant Award Summary Yale University received a $3.3 million Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded September 19, 2025, with completion scheduled for September 18, 2029. This research project investigates the prefrontal mechanisms underlying social interaction strategies by developing and utilizing novel neurobiological tools including automated behavioral paradigms, video-based tracking...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $818,253 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) beginning July 1, 2025, and extending through April 30, 2030. This Project Grant supports a five-year research investigation examining neuromodulatory system abnormalities in late-life depression (LLD), with specific focus on the associations between structural and functional brain...
- Federal Grant Award Summary New York University School of Medicine received a $771,272 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) on March 15, 2026, with a project completion date of December 31, 2030. This research initiative examines prenatal maternal brain plasticity and its associations with maternal and infant neurobehavioral health. The project addresses critical gaps in understanding how the...
- Federal Project Grant Award Summary Yale University received a $838,378 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) effective March 10, 2026, with a completion date of February 28, 2031. This basic neuroscience research project investigates the neural mechanisms underlying infant social behaviors and learning, specifically examining how somatostatin-expressing neurons in the zona incerta (ZISST neurons)...
- Federal Grant Award Summary Yale University received a $665,494 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025 through July 31, 2028. This award supports the development of a Social Interaction Suite (SIS)—an integrated system of synchronized neural and behavioral measurement tools designed to study cognitive networks associated with facial cue processing during live, face-to-face social...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Feinstein Institutes for Medical Research a Project Grant of $519,558 under the Mental Health Research Grants program (CFDA 93.242), effective June 15, 2025 through April 30, 2030. The research project focuses on identifying and validating cerebellar-cortical circuitry biomarkers as predictive indicators of antipsychotic treatment response in first-episode psychosis patients. The primary deliverables...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded $717,688 to Icahn School of Medicine at Mount Sinai under the Mental Health Research Grants program (CFDA 93.242) for a four-year project period from May 1, 2026, through April 30, 2030. This K01 mentored research award funds an investigation into the molecular and epigenetic mechanisms by which postpartum stress interacts with parity to influence vulnerability to perinatal or postpartum mood and anxiety...
The National Institute of Mental Health (NIMH) awarded Yale University a $839,329 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to conduct the first in vivo human positron emission tomography (PET) imaging study examining synaptic density changes during menopause. The project, which commenced May 1, 2026 and extends through February 28, 2031, will investigate how menopause affects synaptic vesicle glycoprotein 2A (SV2A)—a marker of synaptic density—in corticolimbic brain regions and whether major depressive disorder (MDD) exacerbates these menopause-related alterations. Research will establish the relationship between objective and subjective measures of mood and cognitive function and observed synaptic changes, addressing a critical gap in understanding neurobiological mechanisms underlying depression and cognitive decline in women during menopause. This research directly supports NIMH's mission to transform understanding and treatment of mental illnesses through basic and clinical research. By identifying synaptic density as a potential neurochemical mechanism linking menopause, depression, and cognitive impairment, the study will generate peer-reviewed publications, neuroimaging datasets, and mechanistic insights essential for developing targeted interventions addressing mood and cognitive alterations experienced during menopause—conditions for which currently no effective treatments exist.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $839.3k | 4/13/26 |