Project Grant R01MH142539
- The National Institute of Mental Health awarded The Leland Stanford Junior University $192,192 on April 15, 2026, to develop an artificial intelligence foundation model for functional neuroimaging that predicts treatment response, stratifies patients, and identifies biotypes in major depressive disorder under CFDA 93.242 (Mental Health Research Grants). The award funds three specific aims. Aim 1 applies pooled functional MRI data from individuals with major depressive disorder to fine-tune a...
- The National Institute of Mental Health awarded the University of Southern California $751,034 on August 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a neuroscience research project examining how the brain processes uncertainty in noisy, dynamically changing environments. The project, titled "Unraveling Neural Mechanisms Underlying Learning in a Noisy, Dynamically Changing World," investigates computational and neural mechanisms by which the brain...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded the University of California, Los Angeles $772,569 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct highly parallel analysis of high-confidence autism spectrum disorder and schizophrenia risk gene mechanisms. The recipient will study approximately 50 risk genes identified as harboring rare, protein-disrupting heterozygous mutations associated with these neuropsychiatric disorders. The work leverages a...
- The National Institute of Mental Health awarded California Institute of Technology $1,417,650 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop instrumentation for synchronized multimodal recording and analysis of human behavior and neural activity during complex, unstructured tasks. The project develops a system to acquire and synchronize behavioral data streams including head-mounted eye tracking to monitor gaze position, egocentric and...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $534,191 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop robust fine-mapping tools for genetic discovery in neuropsychiatric traits using deep phenotype data from diverse populations. The project addresses the challenge of understanding genetic causes of complex neuropsychiatric conditions including autism spectrum disorders, bipolar disorder, and...
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
- The National Institute of Mental Health awarded the University of Southern California $1.509 million on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning risk prediction models for persistent adverse mental health outcomes in autistic children and youth, leveraging social determinants of health from electronic health record data. The research uses natural language processing to extract social and ecological factors from clinical notes...
- The National Institute of Mental Health awarded Beth Israel Deaconess Medical Center, Inc. $2.961 million on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop standardized digital health data formats for mental health research and clinical care. The award funds five integrated aims. Aim 1 establishes a multidisciplinary consortium of clinicians, researchers, industry representatives, regulators, and patient advocates to develop a governance framework...
- The National Institute of Mental Health awarded the University of California, Los Angeles $118,404 under the Mental Health Research Grants program (CFDA 93.242) on July 1, 2026, to support research examining dynamic functional network biomarkers of emotion regulation flexibility in internalizing disorders. The research addresses transdiagnostic biomarkers for internalizing disorders including depression, anxiety, and posttraumatic stress. The recipient will analyze a large-scale longitudinal...
The National Institute of Mental Health awarded the University of Southern California $1.105 million on August 7, 2026, under the Mental Health Research Grants program (CFDA 93.242) to establish a global framework for harmonized functional MRI analysis in psychiatry. The project will harmonize resting-state fMRI datasets across eight psychiatric and neurodevelopmental disorders—schizophrenia, bipolar disorder, post-traumatic stress disorder, major depression disorder, obsessive compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, and anorexia nervosa—drawing on data from over 1,000 laboratories across 45 countries. The work includes two core aims: developing AI tools to create standardized analysis protocols, quantify methods-related variance, and perform image quality control; and isolating and validating functional connectivity biosignatures across the eight disorders on a cohort of 15,719 cases and 20,225 controls to identify shared and distinct patterns. Work will be performed in Marina Del Rey, California, with a foreign subaward component. The award runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.4k | 8/20/26 | ||
| Not listed | $455.3k | 8/11/26 |