This Project Grant award of $618,863 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the neural dynamics of fear circuits in rodent models of risk and trauma. The key objectives are to: Test the hypothesis that the amygdala functions as a central relay, processing threat information from the midbrain and transmitting fear signals to corticolimbic structures to guide risky decision-making. This will...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research focused on understanding the neurocircuitry underlying motivated reward-seeking behavior following exposure to stress. The $606,029 award to the University of Massachusetts Medical School aims to elucidate the role of the medial habenulo-interpeduncular nucleus (MHB-IPN) axis in modulating reward-seeking as a coping...
The National Institute of Mental Health (NIMH) awarded a $418,750 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Yale University to mechanistically uncover the neuroanatomical substrates of anxiety-related brain circuits in humans. The 5-year project aims to dissect the individual and complementary roles of the dorsal anterior cingulate cortex and anterior insula in safety assessment and aversive outcomes response during spatial threat avoidance tasks. Using invasive...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $211,248 to the University of California, Los Angeles (UCLA) to conduct research on the neural mechanisms governing fear and anxiety responses within the hippocampal-amygdala circuit in humans. The key products and services to be delivered include: Elucidating how the acquisition, extinction, and renewal of fear and anxiety responses...
This federal Project Grant awarded by the National Institute of Mental Health (NIMH) supports research on the role of prefrontal dopamine circuits in threat avoidance learning. The $2,055,184 award to the University of California, Los Angeles (UCLA) under CFDA Program 93.242 - Mental Health Research Grants aims to measure and manipulate dopamine and medial prefrontal cortex neuron activity in mice to understand the neural mechanisms underlying flexible threat avoidance learning. The research...
This federal Project Grant award (R01MH138428) for $681,690.00 was issued by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports a longitudinal intergenerational study to examine the development and transmission of threat sensitivity, a key neurocognitive risk factor for anxiety disorders, in 300 mother-child dyads. The study utilizes a multi-method assessment framework, including psychiatric, behavioral, observational,...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $392,500.00 to the University of California, Irvine to conduct research on the developmental programming of the human hypothalamus and its role in motivated behaviors. The research project, which runs from January 1, 2025 to December 31, 2029, aims to investigate the impact of early life adversity on the structure and function of the developing...
This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the neural substrates underlying the encoding and retrieval of higher-order fear memories. The $1,072,702 award to the University of Vermont aims to use chemogenetic and electrophysiological techniques in freely moving rats to elucidate the cortical network properties that allow stimuli not directly paired with trauma...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants, supports research to identify cell types in the extended amygdala and nucleus accumbens that modulate social behavior and anxiety. The $885,500 award, effective July 3, 2024 through June 30, 2026, will enable researchers at the University of California, Davis to utilize the FLICRE system to tag and genetically profile specific neuronal cell...
This Project Grant award, totaling $197,235.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant will support a four-year research career development program for an MD/PhD candidate to study the circuit physiology of cognitive flexibility, which has relevance for symptoms seen in conditions like schizophrenia, autism spectrum disorder, and post-traumatic stress disorder. The proposed research will...