Project Grant R01MH139476
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $781,358 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective April 1, 2026 through December 31, 2030. The award funds research to determine the mechanisms and therapeutic potential of novel cholinergic antipsychotics for treating schizophrenia. The project will employ in vivo imaging, microdialysis, and behavioral...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $737,726 Project Grant award dated September 23, 2025, from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds fundamental neuroscience research conducted at Northwestern's Evanston, Illinois campus through May 31, 2030. The project delivers rigorous scientific investigation...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $106,922 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 26, 2026, with completion targeted for October 31, 2028. The award supports investigator-initiated biomedical research examining the pathogenic mechanisms underlying food allergen absorption and anaphylaxis risk....
- Federal Grant Award Summary Northwestern University received a $200,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 4, 2025, with a completion date of August 31, 2027. The award supports biomedical research focused on identifying and validating microRNAs (miRNAs) that regulate neutrophil transendothelial migration (TEM) in gut inflammation. The research...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of California, Los Angeles a $125,556 Project Grant effective October 25, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neuronal mechanisms underlying avoidance and pursuit behaviors during human navigation. The research will identify medial temporal lobe (MTL) population oscillatory and single-neuron mechanisms that support simultaneous reward-seeking and...
- Federal Project Grant Award Summary Emory University received a $782,279 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective August 1, 2025, through May 31, 2030. The award funds an interdisciplinary research initiative titled "Quantifying Neural Signatures of Multi-Step Avoidance Behavior in Anxiety," which aims to develop and validate a novel computational model of avoidance behavior in...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of Miami a $731,258 Project Grant, effective March 1, 2026, through November 30, 2030, under the Mental Health Research Grants program (CFDA 93.242). This research project aims to map neural dynamics associated with Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) by utilizing high-stakes, real-world events as stimuli. The study will employ functional magnetic resonance imaging...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Trustees of Columbia University in the City of New York a Project Grant of $126,900 under the Mental Health Research Grants program (CFDA 93.242) for research extending from April 2, 2026, through March 31, 2028. This award funds basic neuroscience research investigating the cellular and circuit mechanisms underlying value representation in the mouse medial prefrontal cortex (mPFC), a brain region essential...
- Federal Grant Award Summary The University of Toledo Health Science Campus Division received a $545,759 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025, through May 31, 2027. The project, titled "Serotonin-Mediated Reorganization of the Adolescent Medial Prefrontal Cortex," investigates the neurobiological mechanisms underlying anxiety disorders in adolescents and the...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Illinois a $721,485 Project Grant (CFDA 93.242: Mental Health Research Grants) on March 15, 2026, for a three-year project period concluding March 14, 2029. This R34 developmental research grant supports the design and development of a digital low-intensity mental health treatment intervention ("CPKD D-LITE") integrated into Chicago Park District (CPKD) teen programming. The project...
Northwestern University's Sponsored Research Division received a $708,139 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective April 1, 2026 through December 31, 2030. This award supports a four-year research initiative investigating the neurobiological mechanisms linking allergic inflammation to heightened avoidance behaviors associated with mood and anxiety disorders. The research employs integrated molecular, cellular, and circuit-level approaches to elucidate how interleukin-4 (IL-4), a key T helper cell type 2 cytokine elevated during allergic inflammation, modulates neural circuits in the medial prefrontal cortex (MPFC) and basolateral amygdala (BLA) to drive avoidance behavior. The project deliverables consist of peer-reviewed scientific publications, mechanistic insights into brain function and mental health pathophysiology, and potential novel therapeutic targets for treating anxiety and mood disorders. Across three integrated research aims, the funded work will establish the quantitative relationship between MPFC IL-4 levels and avoidance behavior during allergic inflammation, identify local IL-4-producing cell types, characterize how IL-4 functions as a non-classical neuromodulator affecting MPFC-BLA circuit activity and output, and determine the necessity of MPFC IL-4 receptor alpha in allergic inflammation-associated behavioral responses. These research products advance NIMH's mission to transform understanding and treatment of mental illnesses through basic and clinical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $708.1k | 3/26/26 |