Project Grant R01MH138484
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $221,302 Project Grant on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242). This two-year exploratory research project (R21 grant mechanism) aims to systematically assess the impact of mandatory National Institutes of Health (NIH) neuroethics requirements on the ethical design and conduct of brain-related human subjects research. The primary deliverables...
- Federal Grant Award Summary The University of Pennsylvania received a $162,486 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded on December 14, 2025, with completion targeted for June 30, 2027. This research initiative, titled "Mapping the Functional Organization of the Cortex Across Development: The Principal Hierarchy and Transdiagnostic Psychopathology Risk," will deliver comprehensive...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $200,376 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) effective April 1, 2026, with a completion date of March 31, 2031. This five-year research initiative investigates intergenerational stress transmission mechanisms by examining how prenatal maternal inflammation (PMI) affects child mental health outcomes, both...
- Federal Grant Award Summary The University of Pennsylvania received a $147,486 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded on September 21, 2025, with a completion date of June 30, 2028. This research project aims to differentiate primary and secondary subtypes of callous-unemotional (CU) traits in early childhood by examining distinct physiological and etiological pathways. The study involves 500...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $467,368 Project Grant to the Research Foundation For Mental Hygiene, Inc. (New York State Psychiatric Institute) under the Mental Health Research Grants program (CFDA 93.242) for the period April 1, 2026 through March 31, 2028. This exploratory/developmental research grant (R21) investigates the relationship between gestational serotonin levels and offspring neurodevelopment by analyzing existing data from an...
- The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $431,750 Project Grant to Rutgers, The State University of New Jersey. The award will fund research into the molecular mechanisms behind the sex-specific deficits observed in neurodevelopmental disorders such as autism spectrum disorder (ASD). The research aims to investigate how hormones and sex-specific signaling interact in the development of behavioral deficits, using...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pittsburgh $437,250 under the Mental Health Research Grants program (CFDA 93.242) for a two-year exploratory research project spanning April 1, 2026 through March 31, 2028. This R21 project delivers neuroscience research services investigating parvalbumin interneuron (PVI) diversity and neuroplasticity in primary visual and prefrontal cortical areas. The research employs patch-seq methodology...
- Summary of Federal Project Grant Award The National Institute of Mental Health (NIMH) awarded The University of Texas Southwestern Medical Center a project grant of $609,386 under the Mental Health Research Grants program (CFDA 93.242) to conduct fundamental research on the regulation and function of DNMT3A-mediated methylation in the brain. The award, effective August 26, 2025, through May 31, 2030, will support research investigating how phosphorylation of the DNA methyltransferase DNMT3A...
- Federal Grant Award Summary New York University School of Medicine received a $771,272 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) on March 15, 2026, with a project completion date of December 31, 2030. This research initiative examines prenatal maternal brain plasticity and its associations with maternal and infant neurobehavioral health. The project addresses critical gaps in understanding how the...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of Colorado-Denver $429,000 under the Mental Health Research Grants program (CFDA 93.242) for a two-year exploratory research project spanning June 1, 2025 through May 31, 2027. The project, titled "A Synaptogenic Adhesion Code for Myelin Specificity," investigates the molecular mechanisms underlying myelin formation and white matter abnormalities associated with autism spectrum disorder (ASD)...
The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $689,249 Project Grant under the Mental Health Research Grants program (CFDA 93.242) on April 15, 2026, to support research investigating sex-specific mechanisms by which maternal immune activation (MIA) during pregnancy impacts cortical development and increases neurodevelopmental disorder risk. The research focuses on the CXCR7 (ACKR3)/CXCL12 chemokine signaling axis and addresses critical knowledge gaps regarding why male offspring demonstrate increased vulnerability to conditions such as autism spectrum disorder and schizophrenia compared to females. The project deliverables through January 31, 2031 include mechanistic insights derived from two coordinated research aims: (1) investigation of the physiological role of the CXCR7/CXCL12 axis in corticogenesis using ACKR3 knockout models and epigenetic profiling to examine sex-specific neural progenitor cell differentiation and migration; and (2) examination of pathophysiological responses to MIA through advanced molecular techniques assessing cortical disorganization, precocious neural progenitor cell maturation, and behavioral changes associated with neurodevelopmental disorders. Research products will include peer-reviewed publications, mechanistic data on intrinsic sex differences in brain development, and molecular findings relevant to understanding environmental factors influencing vulnerability to neurodevelopmental disorders.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.2k | 4/17/26 |