The University of Southern California (USC) Department of Contracts and Grants Division received a $772,745 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The funding supports a research project titled "Non-Synaptic Function of SYNGAP1 in Human Neurodevelopmental Disorders" that aims to determine the downstream effectors and functional role of the SYNGAP1 gene in human radial glial progenitor cells during early brain development. The project will leverage human brain organoid models to investigate how SYNGAP1 mutations impact cortical neurogenesis and identify associated protein interaction networks linked to neurodevelopmental disorders. This work is expected to provide new insights into the early developmental mechanisms underlying SYNGAP1-related psychiatric conditions and inform the selection of potential therapeutic targets. The award has an effective date of March 1, 2025 and is scheduled for completion by December 31, 2029.
Generated 3/18/25, 5:03 AM