This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 Mental Health Research Grants provides funding of $711,361 to Loyola University of Chicago's Health Sciences Campus Division to conduct research on sex differences in cognitive dysfunction and the potential mitigation by RNA editing.
The key objectives of the research are to: 1) Determine if GLUA2 RNA editing mediates the long-term impact of prenatal stress on cognitive function and stress resilience, and 2) Identify sex differences in these processes. The research will use genetically modified mouse models to study synaptic plasticity, gene expression, and behavioral outcomes in the hippocampus and amygdala following prenatal stress exposure. This work has the potential to elucidate novel molecular mechanisms underlying sex differences in the effects of stress on cognition and uncover new therapeutic targets for enhancing stress resilience.
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