The University of Texas at Austin was awarded a $636,834 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The grant's objectives are to: 1) Identify downregulated molecular profiles in the anterior insula and subgenual anterior cingulate brain regions in bipolar disorder and bipolar disorder suicide deaths using bulk tissue RNA sequencing, and 2) Identify downregulation of molecular profiles in these brain regions in bipolar disorder suicide deaths at the cellular level using single-nucleus RNA sequencing. The goal is to elucidate the brain mechanisms and molecular abnormalities underlying suicide risk in bipolar disorder, particularly in older men who have a disproportionately high suicide rate. The University of Texas Health Science Center at Houston was awarded a $1,503 sub-grant to contribute to this research on brain circuitry and cellular gene expression profiles related to suicide in bipolar disorder. The project period runs from May 15, 2024 to February 28, 2029.
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