The National Institute of Mental Health (NIMH) awarded a 5-year, $678,430 Project Grant (CFDA 93.242 Mental Health Research Grants) to the University of California, Berkeley to investigate the frontostriatal neural dynamics underlying compulsive behaviors. The research aims to test the hypothesis that the orbitofrontal cortex inhibits habitual responses in the striatum to enable goal-directed decision-making. Using a novel behavioral task and cutting-edge Neuropixels neural recording techniques, the project will examine the role of alpha-band coherence between the orbitofrontal cortex and caudate nucleus in this inhibitory control process. Findings from this work are expected to lay the groundwork for developing devices that can meaningfully interact with these frontostriatal circuits, with potential applications for treating neuropsychiatric disorders involving compulsive behaviors.