The University of California, Los Angeles (UCLA) received a $776,444 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The award, effective September 1, 2024 through April 30, 2029, will fund a study to identify unique neural and inflammatory mechanisms contributing to depression in people living with HIV (PLWH).
The key research activities include using functional MRI to measure brain network connectivity and function in PLWH with and without depression, as well as HIV-negative individuals with and without depression. The study will also assess peripheral inflammatory markers and pathways to elucidate how HIV status, inflammation, and depression interact with critical brain networks. This work aims to identify potential biomarkers and treatment targets to improve outcomes for the nearly 60% of PLWH who suffer from depression. The findings could guide future intervention efforts to address this significant health challenge.
Generated 3/4/25, 6:34 AM