Project Grant R01LM014714
- Cornell University was awarded a $1,317,788 project grant from the National Science Foundation Division of Integrative Organismal Systems to develop tools for host-microbiome protein-protein interaction discovery and establish sequencing-compatible ultra-high-throughput experimental screening approaches. The grant also supports the launch of annual bioinformatics hackathons for students centered on protein structure-inspired projects and the development of computational tools to assign...
- This federal Project Grant award of $277,380.00, provided by the Office of the Director at the U.S. Department of Health and Human Services under the Trans-NIH Research Support program (CFDA 93.310), supports the development of novel statistical methods for detecting microbiome-metabolome interactions. The research aims to create a powerful transfer-learning framework for high-dimensional regression models to uncover associations between gut microbes and their metabolites, which play a...
- This $351,000 federal Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.879 - Medical Library Assistance) supports research to measure and improve the innovative potential of biomedical research and translation. The project develops computational, data, and network science tools integrated with a social science framework to analyze discovery and innovation dynamics, with the goal of accelerating transformative breakthroughs in biomedical fields. The...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) in the amount of $300,000 supports research by Duke University to develop an integrated experimental and computational approach to uncover the design principles governing microbiome function. The key objectives are to apply advanced machine learning techniques, high-throughput microbial community construction, and metabolomics to elucidate the molecular networks and cellular...
- This $985,496 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by the University of Rochester to develop an innovative platform for controlling and stabilizing microbial communities. The project aims to leverage horizontal gene transfer, specifically through plasmid conjugation, to dynamically balance growth rates and community composition, creating programmable microbial populations capable of maintaining stability across...
- This federal Project Grant award of $914,479 from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a research project led by The Trustees of Columbia University in the City of New York to study the spatial organization and stability of synthetic gut microbiome communities in gnotobiotic mice. The research aims to elucidate the principles governing the assembly and persistence of microbial communities in the human digestive tract, which are essential for human...
- The National Institute of General Medical Sciences (NIGMS) awarded a $557,900 Project Grant to the Massachusetts Institute of Technology (MIT) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds a long-term research strategy to study ongoing adaptation and selective forces within human microbiomes. Using a culture-dependent genomic approach, the project aims to characterize within-person evolution over a dozen microbial species found in the skin, vagina,...
- This Project Grant award of $434,472.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by Claremont McKenna College to develop novel computational methods for inferring microbial associations from microbiome data. The project aims to address challenges in determining the underlying covariance structure and modeling positive and negative interactions between microbial taxa. The resulting computational tools and algorithms will enable new...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,931.00 to the University of Colorado-Denver to characterize how specialized microbial metabolites mediate interactions within the human microbiome. The research aims to elucidate the role of these metabolites in enabling microbial communities to resist antimicrobial therapies, with the goal of improving...
- The federal Project Grant award of $1,602,000.00 from the National Institute of Environmental Health Sciences, under the Medical Library Assistance program (CFDA 93.879), will support the development of computational methods for analyzing multiplex immunofluorescence (MIF) imaging data to study the tumor microenvironment. The project aims to leverage a unique MIF dataset from over 2,000 cancer patients across 20 tumor types to develop innovative computational strategies, including spatial...
The federal Project Grant award under the Medical Library Assistance program (CFDA 93.879), administered by the National Institute of Environmental Health Sciences, aims to accelerate data-driven and experimental discovery of protein-protein interactions between the human host and microbiome. The $1,841,206 award, granted on Sep 5, 2025, supports the development and validation of a computational pipeline to predict novel host-microbiome protein interactions, and the experimental application of proximity labeling to identify novel receptor-ligand interactions. The grant recipient, Cornell University, will leverage protein language models, structure prediction tools, and experimental methods to expand the understanding of molecular mechanisms underlying associations between the microbiome and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 9/5/25 |