Project Grant R01HL188399
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $776,745 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to define and target DELE1-mediated mitochondrial stress signaling in cardiomyopathy. The research addresses how mitochondrial dysfunction drives cardiovascular disease, including heart failure and ischemic injury, by characterizing the molecular mechanisms through which DELE1 acts as a mitochondrial stress sensor to...
- The National Heart, Lung, and Blood Institute awarded University of California, Los Angeles $1,567,702 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the safety and mechanisms of cardioneural ablation, an emerging interventional therapy targeting excessive vagal tone in patients with vasovagal syncope. The project defines mechanisms underlying cardioneural ablation–associated ventricular arrhythmias to enable safer and more effective clinical...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $760,156 for Project Grant R01HL179001 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds investigation of neural mechanisms underlying metabolic-ventilatory coupling during thermogenesis. The research addresses how metabolic rate and ventilation coordinate during cold exposure—a three-to-five-fold increase in both without disrupting blood gas homeostasis—using a...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $760,465 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop deep learning methods that advance cardiac magnetic resonance strain imaging for personalized cardiac resynchronization therapy treatment planning. The award funds development of deep strain networks to rapidly and accurately predict myocardial displacements from cardiac magnetic resonance imaging, addressing...
- The National Institutes of Health National Heart Lung and Blood Institute awarded The University of Central Florida Board of Trustees $1,409,894 on September 12, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to map vagal and spinal afferent innervation of healthy and diabetic rat and human hearts and characterize mechanosensitive and nociceptive cardiac afferent neurons. The work includes retrograde and anterograde tracer injection into rat hearts, vagal nodose...
- The National Heart, Lung, and Blood Institute, part of the Department of Health and Human Services, awarded $1,619,582 to the University of Virginia on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the cardio-splenic axis in acute myocardial infarction and post-MI heart failure. The project examines the immunopathological mechanisms by which plasmacytoid dendritic cells orchestrate post-MI inflammation and cardiac dysfunction. The research team...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $429,000 Project Grant to The Regents of the University of Colorado (University of Colorado-Denver) under the Cardiovascular Diseases Research program (CFDA 93.837) for a two-year project period (September 1, 2025 – August 31, 2027). The award supports research investigating the impact of selective vagal neuromodulation on heart failure indices. The primary deliverables include preclinical...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $248,999 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the molecular mechanisms regulating T-tubule structure in the mammalian heart during mechanical load conditions. The research will employ novel magnetorheological elastomer culture systems to subject isolated cardiomyocytes to pathological overload while comprehensively characterizing excitation-contraction...
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $799,256 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate cardiac protection through neuromodulation after myocardial infarction. The project, designated R01HL183128, will conduct research on the interplay between cardiac injury signals, brain integration, and peripheral sympathetic outflow following myocardial infarction. The work spans three...
- The National Heart, Lung, and Blood Institute awarded President and Fellows of Harvard College $133,232 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate neural control of cardiovascular physiology via heart-to-brain signaling pathways. The recipient, operating through Harvard Medical School's Office of Research Administration, will conduct research to elucidate how genetically distinct populations of vagal cardiac sensory neurons detect and respond...
The National Heart, Lung, and Blood Institute awarded the University of Virginia $721,977 on August 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to uncover the molecular and functional organization of cardiovagal neurons that regulate heart rate through the vagus nerve. The project will map the synaptic inputs, outputs, and functional sufficiency of two distinct cardiovagal neuron subtypes—NPY2R-expressing neurons in the nucleus ambiguus and VIP-expressing neurons in the dorsal motor nucleus of the vagus—using anterograde tracing, intersectional chemogenetics, and rabies-based molecular connectomics. Preliminary work has identified these subtypes as functionally distinct: the ventral neurons are activated during the diving reflex and appear to provide reflexive, bottom-up control of heart rate, while the dorsal neurons integrate signaling related to stress and feeding, mediating top-down control. The research will test the hypothesis that these opposing control pathways explain how different physiological stimuli engage distinct cardiovagal circuits to maintain normal cardiac rhythm and protect against arrhythmias and heart failure. Performance occurs in Charlottesville, Virginia. The period of performance extends through May 31, 2030. This is a Project Grant, the standard assistance type for individual research projects under NHLBI's competitive grant program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $722.0k | 8/25/26 |