Project Grant R01HL187968
- The National Heart, Lung, and Blood Institute, under the Department of Health and Human Services National Institutes of Health, awarded The Washington University $768,128 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to mechanistically evaluate the role of oscillatory shear stress in deep vein thrombosis prevention. The recipient will conduct in vitro, in vivo, and human model studies to determine whether restoration of oscillatory shear stress in veins...
- The National Heart, Lung, and Blood Institute awarded the University of Washington $1.608 million on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate genomic and proteomic determinants of recurrent venous thromboembolism. The research addresses the high rate of recurrent venous thromboembolism (VTE) events—either deep vein thrombosis or pulmonary embolism—occurring in 20–30% of survivors within five years. Current anticoagulant therapies, while...
- The National Heart, Lung, and Blood Institute awarded Versiti Blood Health, Inc. $1,069,072 on March 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to decode kindlin-3 signaling in platelets and neutrophils. The research investigates the regulatory role of kindlin-3, a critical signaling adaptor in hematopoietic cells, in thrombosis and inflammation. The project focuses on elucidating molecular mechanisms by which kindlin-3 regulates platelet activation during...
- The National Heart, Lung, and Blood Institute awarded Yale University $577,016 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 1, 2026, to support research into the molecular mechanisms underlying endothelial von Willebrand factor exocytosis. The research addresses how von Willebrand factor (VWF), a multifunctional plasma glycoprotein essential to hemostasis and thrombosis, is mobilized from vascular stores in endothelial cells. VWF is synthesized and stored in...
- The National Heart, Lung, and Blood Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded $697,198 to the University of Texas at Austin on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sex-biased integrin-mediated endothelialization processes for precision vascular graft design. The recipient is conducting research to identify how biological sex affects endothelial cell behavior in response...
- The National Heart, Lung, and Blood Institute awarded the University of Wisconsin – Madison $521,101 on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of macrophages and hematopoietic stem cell trogocytosis in the bone marrow niche. The research defines mechanisms by which hematopoietic stem cells acquire macrophage-associated markers through trogocytosis—rapid transfer of membrane-bound proteins from adjacent cells—and examines how this...
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $1.6 million under the Cardiovascular Diseases Research program (CFDA 93.837) on September 1, 2026, to investigate GA12-dependent mechanisms of basal and regulated endothelial cell von Willebrand factor (VWF) secretion. This is a Project Grant (R01HL186410). The research addresses microvascular thrombotic occlusions in inflammatory conditions such as sepsis and sickle cell disease, where elevated VWF plasma levels...
- The National Heart Lung and Blood Institute awarded The Johns Hopkins University $175,874 on July 6, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a prospective, three-center cohort study investigating clinical risk factors and biomarkers for recurrent venous thromboembolism in children with cardiac disease. The research addresses the elevated risk of recurrent VTE events—including deep vein thrombosis and pulmonary embolism—in children with congenital and...
- The National Heart, Lung, and Blood Institute awarded the Scripps Research Institute $1,101,338 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to engineer noncovalent antibody-enzyme thrombolytic complexes that function orthogonally to the natural hemostatic system. The project, R01HL184492, addresses limitations of current plasminogen activator therapies—including narrow therapeutic window, contraindications, and risks of neurotoxicity, bleeding, and...
- The National Heart, Lung, and Blood Institute awarded New York University $872,787 on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct proteomic discovery and validation research on chronic limb-threatening ischemia (CLTI), the most severe form of peripheral artery disease. The award funds development of proteomic signatures to predict major adverse limb events (MALE) and major adverse cardiovascular events (MACE) in CLTI patients, and to guide...
The National Heart Lung and Blood Institute (NHLBI), a component of the Department of Health and Human Services National Institutes of Health, awarded $743,131 to the University of Wisconsin - Madison on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate regulatory mechanisms of the vessel wall in deep vein thrombosis. The research addresses thrombospondin-1 (TSP1), a matricellular protein upregulated in endothelial cells during DVT. The project tests the central hypothesis that endothelial TSP1 exerts a protective, anti-thrombotic effect by suppressing hypoxia-inducible factor 1-alpha (HIF1A) signaling and associated pro-thrombotic vascular inflammation. Aim 1 will establish the functional link between endothelial TSP1 and HIF1A-driven vascular inflammation using HIF1A modulators in transgenic mice with endothelial-specific TSP1 deletion and human iPSC-derived endothelial cells. Aim 2 will determine the sex-specific drivers of this vascular dysfunction using gonadectomy and four core genotypes mouse models to dissect the contributions of gonadal hormones versus sex chromosomes. This research challenges existing dogma regarding TSP1's pro-thrombotic role and defines a novel anti-thrombotic signaling pathway governing endothelial function and vascular inflammation. Performance of work is based in Madison, Wisconsin. The period of performance runs from August 1, 2026, through June 30, 2031. The award is classified as a Project Grant, a standard assistance type under the NIH research grant structure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $743.1k | 8/5/26 |