Project Grant R01HL186546
- Federal Grant Award Summary The University of Arizona received a Project Grant award of $558,127 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2026, with a completion date of July 31, 2033. This multidisciplinary research initiative, titled "Decoding the Enigma of Cardiac Arrhythmia and Mechanosensitivity," aims to elucidate the role of small conductance calcium-activated potassium (SK)...
- Federal Project Grant Award Summary The University of Arizona received a $1.34 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of June 30, 2029. The award funds basic research investigating the role of hexokinase 3 (HK3) in macrophage polarization and cardiac remodeling following myocardial infarction and ischemia/reperfusion injury. The research...
- Federal Project Grant Award Summary The University of Arizona received a $562,733 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 6, 2026, with completion targeted for May 31, 2027. The award funds research to develop small molecule therapeutics for heart failure by inhibiting tristetraprolin (TTP), a protein that regulates cardiac metabolism and inflammatory responses. The research...
- Federal Project Grant Award Summary The University of Arizona received a $650,419 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with completion targeted for March 31, 2030. The award funds research to develop a comprehensive mechanistic understanding of sarcomeric protein interactions and their role in hypertrophic cardiomyopathy (HCM). The research extends the investigator's...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $169,776 to the University of California, Los Angeles on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The project, "Evaluating Cardiac Neural Control in Atrial Fibrillation," will conduct investigative research through June 30, 2031, to identify and characterize neural targets within the cardiac autonomic nervous system for treating...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $498,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 2, 2025, with a completion date of August 31, 2028. The grant funds basic biomedical research investigating the molecular determinants of atrial fibrillation (AF), the most common serious cardiac arrhythmia affecting an estimated 33.5...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Arizona a $1.57M Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective June 5, 2026, through February 29, 2028, to investigate ATF6 as a regulator of atrial myocyte endoplasmic reticulum (ER) proteostasis. The research focuses on understanding how the transcription factor ATF6 maintains protein homeostasis in atrial myocytes, particularly as it relates to the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Arkansas a $546,654 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective May 1, 2026 through January 31, 2030 to develop computational and experimental platforms for predicting and controlling cardiac fibrosis in heart failure with reduced ejection fraction (HFrEF) patients. The project integrates systems mechanobiology modeling with patient-derived cardiac...
- Federal Project Grant Award Summary The University of Arizona received a $577,065 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2026, with a completion date of May 31, 2031. This research award supports investigation into the roles of endoplasmic reticulum (ER) stress in calcium-dependent cardiac arrhythmias, with particular focus on the ryanodine receptor (RYR2) dysfunction...
- Federal Grant Award Summary Baylor College of Medicine received a $673,598 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with a completion date of June 30, 2029. The project, "Cardiomyocyte-Fibroblast Signaling in Atrial Fibrillation," delivers basic and translational research services investigating molecular mechanisms underlying atrial fibrillation (AF), a...
The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Arizona a Project Grant of $743,545 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period July 15, 2026, through March 31, 2030. The project focuses on applying deep learning computational methods to identify selective small-conductance calcium-activated potassium (SK) channel inhibitors for atrial fibrillation treatment. Atrial fibrillation represents a major public health concern associated with over $26 billion in annual healthcare costs, and current therapeutic options are limited by inadequate efficacy, adverse side effects, or invasiveness. This research aims to leverage the University of Arizona's recent cryo-electron microscopy (cryo-EM) structural determination of SK2 channels to develop novel SK channel modulators with improved selectivity that avoid off-target inhibition of the human ether-a-go-go-related gene (hERG) channel, thereby reducing cardiac safety risks associated with QT prolongation observed in existing therapeutic candidates. The investigative team will leverage machine learning and artificial intelligence techniques to design and optimize SK channel-selective compounds for clinical development as targeted atrial fibrillation therapeutics. This work builds on the team's prior mechanistic discoveries establishing SK channels as viable therapeutic targets and extends insights from existing clinical compounds such as AP30663, which, while demonstrating efficacy against atrial arrhythmias, exhibits problematic off-target hERG inhibition. The research directly supports NHLBI's mission to foster basic and translational cardiovascular science leading to prevention and treatment of heart and vascular diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $743.5k | 7/7/26 |