Project Grant R01HL186252
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $770,000 on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research unraveling endothelial-cardiomyocyte crosstalk in cardiomyopathy using an integrated multimodal approach. The research examines molecular mechanisms by which endothelial dysfunction contributes to cardiac dysfunction in cardiomyopathy, focusing on cell-to-cell signaling between endothelial cells...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $2,339,136 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of phospholamban in regulating perinuclear calcium signaling and pathological cardiac gene expression as a potential therapeutic target for dilated cardiomyopathy. The funded research examines how phospholamban interacts with the scaffold protein AKAP6B at the myocyte outer nuclear...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $767,249 on June 22, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate computational models for designing organ-scale vasculature in biomanufactured cardiac tissues. The project addresses the need for patient-specific engineered tissues to repair complex congenital heart defects, particularly large ventricular septal defects where current surgical approaches...
- The National Heart, Lung, and Blood Institute (NHLBI) at the Department of Health and Human Services awarded The Leland Stanford Junior University $755,271 on August 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop, validate, and clinically evaluate a magnetic resonance imaging method for assessing blood flow hemodynamics in pediatric and young adult congenital heart disease patients. The project will augment 4D-flow MRI capabilities to enable direct...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $1,541,206 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify druggable targets for cancer therapy-induced cardiotoxicity. The research characterizes proteasome inhibitor-induced cardiovascular toxicity through three aims. Aim 1 profiles cell type-specific cytotoxicity using patient-specific induced pluripotent stem cell-derived cardiomyocytes and endothelial...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $768,912 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify and validate genetic variants associated with cardiac differentiation and congenital heart disease. The research integrates artificial intelligence with genome engineering to discover intrinsic gene regulatory networks governing heart development. Stanford will employ a base-resolution neural network...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $509,334 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a high-throughput software package and associated protocols that measure diastolic mechanics in cardiomyocytes using optical microscopy. The project addresses a critical gap in heart failure with preserved ejection fraction (HFpEF) drug discovery. Current tools measure contractile forces and systolic...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $769,846 on July 1, 2026, under Cardiovascular Diseases Research (CFDA 93.837), a Project Grant assistance type. The recipient will develop and apply an integrative genomics toolkit to characterize and engineer edits to regulatory DNA sequences with the goal of reprogramming gene expression for therapeutic applications. The toolkit combines computational models to predict how sequence changes to enhancers...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $768,830 on July 6, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate immune-fibroblast crosstalk in genetic dilated cardiomyopathy. The research integrates patient-specific induced pluripotent stem cells (iPSCs), three-dimensional cardiac organoids embedded in engineered disease-specific niches, CRISPR-based high-throughput screening, single-cell RNA sequencing,...
- The National Institutes of Health National Heart, Lung and Blood Institute awarded The Leland Stanford Junior University $165,887 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate multi-level drivers of pregnancy-related cardiovascular outcomes across the life-course. The award funds research to elucidate mechanisms by which community disinvestment across the life-course influences perinatal cardiometabolic dysfunction and short- and long-term...
The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $516,181 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a prospective observational ancillary study nested within the MIDAS (Milrinone for Prevention of Post-Ligation Cardiac Syndrome) clinical trial. The study uses non-invasive bedside monitoring techniques—near-infrared spectroscopy (NIRS), lung ultrasound (LUS), and targeted neonatal echocardiography (TNE)—to delineate physiologic mechanisms of post-ligation cardiac syndrome (PLCS) in extremely premature infants after patent ductus arteriosus (PDA) closure. NIRS monitoring will detect changes in cerebral and renal tissue oxygenation in infants who develop the primary outcome of death or PLCS (Aim 1) and secondary outcomes of impaired neurodevelopment at 22–26 months (Aim 2). Serial TNE and LUS measures will exploratorily assess left ventricular output and pulmonary edema (Aim 3). The work will characterize the protective mechanisms of milrinone in preventing PLCS across the NICHD Neonatal Research Network's 19 participating centers. Performance occurs at Palo Alto, California, with period of performance from September 1, 2026, through June 30, 2031. The award is classified as a Project Grant, assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $516.2k | 8/19/26 |