Project Grant R01HL185859
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $739,474 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 18, 2025, to investigate the anti-fibrotic roles of stress-induced tRNA-derived small RNAs (tDRs) in cardiac fibrosis. The research will be conducted through May 31, 2030, and focuses on characterizing the mechanisms by which ASP-GTC-3' tDR, a regulatory RNA fragment derived from transfer RNA,...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Tufts University School of Medicine a $1.12 million Project Grant (CFDA 93.837, Cardiovascular Diseases Research) on September 17, 2025, to conduct a multiethnic and multiomics analysis of longitudinal changes in DNA methylation (DNAM) and cardiovascular health. The four-year research initiative, concluding July 31, 2029, integrates longitudinal epigenome-wide DNAM data with behavioral, clinical, genetic,...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Harvard College's Office for Sponsored Programs a Project Grant of $151,040 on February 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The research will be conducted in Massachusetts and is expected to conclude by November 30, 2028. This award funds investigative research into the role of Tolloid (TLD) proteases in atrial fibrosis pathogenesis, specifically examining how TLD...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The University of Texas Southwestern Medical Center a $1.62 million Project Grant on September 25, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate circulating metabolites underlying cardiometabolic risk for cardiac dysfunction and heart failure in diverse populations. The research employs metabolomics and genomics to identify biologic pathways linking metabolic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a Project Grant totaling $638,176 effective May 1, 2026, through February 28, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). This grant funds basic and translational research investigating thrombospondin-1 (TSP-1), a matricellular protein implicated in cardiac fibrosis associated with heart failure with preserved ejection fraction (HFpEF). The research...
- Federal Project Grant Award Summary Massachusetts General Hospital's Research Management Division received a $867,656 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 1, 2026, with a completion date of February 28, 2031. The award funds research to determine the effectiveness of guideline-directed medical therapies (GDMT) for heart failure with mildly reduced ejection fraction (HFmrEF)—a...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Massachusetts a $425,971 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective July 6, 2026, through June 30, 2028, to develop a biomaterials-integrated microphysiological bone marrow chip model. The project aims to create a physiologically relevant preclinical system that recapitulates the structural and functional interdependence of bone and bone marrow...
- Federal Project Grant Award Summary The University of Arizona received a $562,733 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 6, 2026, with completion targeted for May 31, 2027. The award funds research to develop small molecule therapeutics for heart failure by inhibiting tristetraprolin (TTP), a protein that regulates cardiac metabolism and inflammatory responses. The research...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded University of Massachusetts Medical School a $1.5 million Project Grant (CFDA 93.837, Cardiovascular Diseases Research) effective September 1, 2025, through June 30, 2030, to investigate perivascular adipose tissue (PVAT) as a protective factor against atherosclerotic cardiovascular disease. The research project directly addresses the leading cause of U.S. mortality by examining why certain arteries,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $1.28M to the University of Massachusetts Medical School for research investigating the role of thromboxane A₂ (TXA₂) as a biomarker and mediator of heart failure risk. Under the Cardiovascular Diseases Research program (CFDA 93.837), this award, effective July 15, 2026, through March 31, 2030, funds a multi-site investigation measuring urinary thromboxane B₂ metabolites indexed to renal function across approximately 17,000 participants enrolled in two clinical trials (EMPEROR-Reduced and EMPEROR-Preserved) and two community-based cohort studies (Framingham Heart Study and the Multi-Ethnic Study of Atherosclerosis). The research will examine how systemic TXA₂ generation—primarily from non-platelet tissue sources—contributes causally to heart failure development and progression, with the goal of establishing TXA₂ as both a mechanistic biomarker and therapeutic target. The project deliverables include detailed analyses of the relationship between urinary thromboxane metabolite levels and clinical outcomes in heart failure patients, assessment of disease severity markers, and evaluation of treatment response across the four study populations. By investigating platelet-independent mechanisms of TXA₂ pathogenicity—which existing aspirin therapies do not adequately address—the research aims to identify new therapeutic opportunities for heart failure prevention and management in diverse patient populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/6/26 |