Project Grant R01HL183084
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $855,585 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on August 20, 2025, with an expected completion date of July 31, 2028. The project focuses on developing and adapting an antihypertensive self-titration intervention for implementation in U.S. primary care settings. Given that nearly one in two American adults has...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston University a $649,678 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) on September 2, 2025, to develop the first high-speed wearable Speckle Contrast Optical Spectroscopy (SCOS) system for cuffless blood pressure monitoring. The research addresses a critical clinical need by converting existing benchtop SCOS technology—which uses speckle-based measurements to assess...
- Federal Grant Award Summary Boston University Medical Campus received a $761,599 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for May 31, 2030. The primary deliverable is empirical research quantifying prognostic uncertainty to optimize the implementation of time-limited trials (TLTs) for patients with acute respiratory failure requiring invasive...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston University a $2.93 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to establish the Framingham Heart Study (FHS) Cardiovascular Biobank and Atlas. The award, effective September 1, 2025, through June 30, 2030, addresses critical gaps in understanding how cardiovascular disease (CVD) risk factors affect human cardiac tissue by creating a systematic postmortem...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $709,917 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 17, 2025, with completion targeted for July 31, 2030. This grant funds population genomics research investigating peripartum cardiomyopathy (PPCM), a serious form of heart failure occurring during late pregnancy or shortly after delivery that...
- Federal Project Grant Award Summary Boston University Medical Campus received a $122,625 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) beginning June 1, 2025 and concluding May 31, 2027. The award funds research and development of novel small molecule therapeutics targeting oxidized sirtuin-1 (SIRT1) as a potential treatment for aortic aneurysms in Marfan Syndrome. The research deliverables...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Trustees of Boston University a $644,180 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) effective September 5, 2025, through May 31, 2029, to characterize a newly identified compression-sensitive, cadherin-mediated cell-cell junction and elucidate its molecular mechanisms and biological functions. The research comprises three integrated objectives: defining the structural and molecular...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital $614,843 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a research project examining the relationship between indexed exercise blood pressure and adverse vascular and ventricular remodeling. The project, which will extend through February 28, 2031, investigates whether systolic blood pressure indexed to oxygen consumption...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Colorado-Denver a Project Grant totaling $720,399 effective September 1, 2025, through May 31, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This ancillary study investigates the associations between maternal microbiomes, metabolomes, and hypertensive disorders of pregnancy (HDP) in a racially and ethnically diverse cohort. The research characterizes body-site...
- Federal Project Grant Award Summary The University of Denver received a $263,266 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 2, 2025, with completion targeted for January 5, 2027. This research grant funds a prospective longitudinal study examining the association between discrimination and stressful life experiences reported during pregnancy with cardiovascular disease (CVD) risk in...
Boston University (Trustees of Boston University, doing business as Boston University Medical Campus) received a $651,829 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective May 1, 2026 through January 31, 2031, supports research examining postpartum hypertension and its role in recurrent hypertensive disorders of pregnancy (HDP). The project will construct a longitudinal, medical-record-based cohort at Boston Medical Center, a safety-net hospital where approximately 30% of obstetric patients experience hypertension and over 90% return for care within one year post-delivery, enabling comprehensive investigation of the relationship between postpartum blood pressure control and subsequent HDP recurrence. The research will evaluate modifiable intermediates—including timely capture and management of postpartum hypertension and cardioprotective behaviors such as breastfeeding—as potential pathways to mitigate HDP recurrence. This work addresses a significant public health need, as hypertensive disorders affect more than 10% of U.S. pregnancies and are associated with increased cardiovascular disease risk. By leveraging the postpartum period as an upstream intervention opportunity, the project aims to generate evidence supporting prevention strategies for recurrent HDP that could improve long-term maternal cardiovascular outcomes and inform clinical practice guidelines.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $651.8k | 5/4/26 |