Project Grant R01HL181985
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health, awarded a $1,092,000 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to The Medical College of Wisconsin, Inc. (MCW). The purpose of the grant is to investigate the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system in blood pressure regulation, vascular function, and arterial stiffness. The research aims to advance the understanding of how...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,332,404.00 to The Medical College of Wisconsin, Inc. to investigate the role of basolateral endothelial cilia in promoting vascular stability. The project aims to evaluate the localization of platelet-derived growth factor-BB (PDGF-BB) in the context of the extracellular matrix and basolateral endothelial cilia, examine the role of basolateral endothelial cilia...
- This federal Project Grant award of $618,450.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research focused on identifying key regulators of vascular homeostasis and understanding how they maintain normal vascular function. The principal investigator will use a combination of in silico and in vitro screening approaches to identify the RNA-binding protein PABPC1 as a critical suppressor of endothelial cell activation, which can...
- The Medical College of Wisconsin, Inc. was awarded a $1,559,542 Project Grant from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on February 1, 2025 to study the cardiometabolic impact of gender-affirming hormone therapy in transmasculine young adults. The study aims to better define the vascular and cardiometabolic effects of modern gender-affirming hormone treatment in this population, as research in this area has been limited. The grant will...
- The Medical College of Wisconsin, Inc. was awarded a $151,092 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on macrophage polarization and function in graft-versus-host disease (GVHD). The 5-year grant, awarded on August 1, 2025, aims to define the regulation of interleukin-34 (IL-34) production in intestinal epithelial cells during GVHD, delineate mechanisms by which IL-34 inhibits the emergence of...
- This federal Project Grant award, totaling $135,930, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant supports research on the role of the TRPM7 ion channel in macrophage signaling and its impact on atherosclerosis, a leading cause of cardiovascular disease. The key objectives of the research are to: 1) generate macrophage-specific TRPM7 deletion mice and subject them to a high-fat, Western diet...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $146,013 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Medical College of Wisconsin, Inc. (MCW). The grant, with a performance period from September 1, 2025 to June 30, 2029, will support the use of machine learning models to analyze electronic health record and administrative claims data to better understand the risks of...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $155,321.00 to The Medical College of Wisconsin, Inc. to develop and test a novel, user and patient-centered Vascular Access Pathway (VAP) for the initial delivery of vascular access care in hospitalized children. The 5-year project, which begins on July 30, 2025 and runs through April 30, 2030, aims to: 1) Co-design the VAP for the initial delivery of...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA program 93.837 Cardiovascular Diseases Research is providing $807,948 to support a study on the genetics of left ventricular hypertrophy (LVH) and associated cardiac phenotypes. The primary awardee, The Medical College of Wisconsin, Inc. (MCW), will utilize whole genome sequencing data from the NHLBI TOPMed program to conduct association analyses and identify genetic variants related to LVH....
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $151,523 to The Medical College of Wisconsin, Inc. to investigate the role of fibrinogen in regulating inflammation and thrombus resolution in acute and chronic venous thrombosis. The research aims to develop a novel RNA therapy using lipid nanoparticles to selectively reduce circulating fibrinogen levels and elucidate its impact on thromboinflammatory processes....
The Medical College of Wisconsin, Inc. (MCW) was awarded a $708,108 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the molecular mechanisms of transient receptor potential (TRP) channels, particularly TRPV4, and their role in regulating microvascular endothelial function. The project aims to define the molecular basis of TRPV4 activation by arachidonic acid and its derivatives, as well as the mechanisms of endothelial TRPV4 regulation by protein phosphorylation. The research will employ a combination of functional, biochemical, structural, and computational approaches to advance the understanding of how these polymodal TRP channels contribute to cardiovascular health and disease. The award period runs from August 18, 2025, to May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $708.1k | 8/18/25 |