Project Grant R01HL181150
- This Project Grant award of $2,559,308, funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports a study on the impact of severe pre-eclampsia on heart function in women from diverse racial backgrounds. The study, titled "SHEPREG: Study of Heart Function in Pre-Eclampsia During and After Pregnancy", will evaluate heart function at delivery and 6-12 months postpartum. It aims to describe the cardiomyopathic genetic profile of the...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $285,195 to Brigham & Women's Hospital to refine the process of identifying patients with uncontrolled hypertension and test an intervention for antihypertensive self-titration. The goal is to adapt and implement a strategy where patients can safely and effectively manage their own blood pressure medication dosages in the U.S....
- This federal Project Grant award of $524,179 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a research project at the University of Utah to integrate multi-omics data to understand the heterogeneity of preeclampsia and long-term postpartum hypertension. The project aims to leverage the extensive phenotyping data and biosamples from the NUMOM2B and NUMOM2B-HHS cohorts to identify genetic and environmental risk factors for preeclampsia...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a $661,129 study by Northwestern University to develop and evaluate a technology-enabled strategy to optimize blood pressure management among reproductive-aged women with hypertension receiving care at Federally Qualified Health Centers. The strategy involves integrating electronic health record-based clinical decision support, patient education and home blood...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $166,752 to Boston Medical Center Corporation to conduct a 5-year research project titled "Developing Models of Placenta-Driven Developmental Lung Injury in Human Preeclampsia". The goal is to characterize the impact of human preeclampsia, a pregnancy disease, on fetal lung development and identify placental proteins involved in causing lung...
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on investigating the role of Plasminogen Activator Inhibitor 1 (PAI1) as a potential therapeutic target for maternal endothelial dysfunction in preeclampsia. The $806,978 award, with a performance period from August 1, 2025 to June 30, 2030, will support research at Yale University to gain insights into maternal...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $709,917 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on population genomics and the genetic factors contributing to peripartum cardiomyopathy (PPCM). The research aims to enhance the prediction and early detection of PPCM, a form of heart failure that occurs during...
- This $192,199 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development and piloting of an electronic health record (EHR)-based physical activity intervention to prevent postpartum hypertension progression among women with subclinical blood pressure elevations during pregnancy. The principal investigator, Dr. Natalie Cameron, aims to identify factors influencing postpartum physical activity, develop...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
- The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $751,124 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Kaiser Foundation Hospitals in Pleasanton, CA. The grant supports research to explore the timing and intensity of physical activity, as well as the optimal 24-hour activity compositions, for the prevention of hypertensive disorders of pregnancy, which impact 10-15% of pregnancies and are risk factors for future cardiovascular disease in...
This $658,418 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a randomized, double-blind clinical study to investigate the cardiac effects of mineralocorticoid receptor antagonism in women with prior preeclampsia who have developed chronic hypertension. The study aims to assess whether MR blockade can promote favorable cardiac remodeling and improve coronary microvascular function, independent of blood pressure changes, in order to reduce cardiovascular disease risk in this patient population. The project will be conducted by the Massachusetts General Hospital, a leading academic medical center, over the award period from August 2025 to May 2030. The findings are expected to help establish specific strategies for cardiovascular disease risk reduction in women with a history of preeclampsia.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $658.4k | 8/18/25 |