Project Grant R01HL180977
- Federal Project Grant Award Summary The University of Florida Division of Sponsored Research received a $228,750 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective April 1, 2026 through March 31, 2028. The award funds research on pain phenotypes in advanced peripheral arterial disease (PAD), specifically chronic limb-threatening ischemia (CLTI). The project aims to characterize pain in CLTI patients...
- Federal Project Grant Summary Yale University received a $841,906 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 15, 2026, with completion scheduled for February 28, 2031. The award funds the SICKLE PAIN RELATED IMPACT (SPIRIT-2) Study, which will develop and validate patient-centered endpoints, identify novel blood-based biomarkers, and establish long-term outcome predictors for...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $1.44 million Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective August 15, 2025 through May 31, 2029 to develop mechanistic mathematical models of oxygen-dependent hemoglobin polymerization in sickle cell disease (SCD) at the single-cell level. The research addresses a critical gap in understanding heterogeneity in sickle hemoglobin...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Medical College of Wisconsin, Inc. a Project Grant totaling $122,840 (awarded August 1, 2025; completion July 31, 2030) under the Cardiovascular Diseases Research program (CFDA 93.837). This K24 mentored research award supports Dr. Amanda Brandow's development as a mid-career physician-scientist mentor while advancing clinical investigation into acute and chronic pain in individuals with...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $2,099,364 on September 18, 2025, by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate novel computational and clinical tools for understanding variability in sickle cell disease (SCD) pain experiences. The project, titled "Advancing a Holistic Understanding of Variability in Lived Experience...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Texas at Arlington a $1,098,640 Project Grant on September 18, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support the Modeling Inter-individual Differences to Address Pain of Sickle Cell Disease (MIDAS) project through August 31, 2030. This research initiative addresses critical disparities in pain management for Black adolescents and young adults with sickle cell...
- Federal Project Grant Award Summary The University of Minnesota received a $1.57 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 1, 2026, with completion by February 29, 2028. The award funds mechanistic research into chronic graft-versus-host disease (CGVHD) pathobiology and the development of novel anti-fibrotic therapies. Using state-of-the-art murine models and advanced molecular...
- Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Drexel University a $503,870 Project Grant effective September 1, 2025 through June 30, 2029 under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct fundamental research on anti-sickling therapies for sickle cell disease. The project aims to develop mechanistic understanding of how fetal hemoglobin (HbF) modulates hemoglobin S (HbS) polymerization and inhibits sickle fiber formation....
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of North Carolina at Chapel Hill a Project Grant of $761,028 (awarded September 15, 2025, with completion targeted for June 30, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multi-site prospective study examining sleep-associated hypoxemia in adults with sickle cell anemia (SCA). The research will investigate the prevalence, clinical impact, and treatment...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of Colorado–Denver a Project Grant totaling $111,626 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period August 1, 2025, through July 31, 2027. This research initiative focuses on investigating macrophage populations as a therapeutic target to attenuate pulmonary hypertension (PH) associated with sickle cell disease (SCD). The project will deliver...
Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $746,979 to the Regents of the University of Minnesota (award date: July 15, 2026; completion date: April 30, 2030) under the Cardiovascular Diseases Research program (CFDA 93.837). This research project will investigate the mechanistic basis of acute pain associated with vaso-occlusive crises in sickle cell disease, focusing on the role of lysophosphatidic acid (LPA) metabolism and its pathway through peroxisome proliferator-activated receptor-gamma, hypoxia-induced factors, and nociceptor sensitization. The research utilizes transgenic mouse models to elucidate how hypoxia-induced aberrant LPA metabolism in bone marrow leads to elevated LPA levels and pain sensitization through LPA receptor 1 signaling on dorsal root ganglia neurons. The project will deliver research findings and experimental evidence regarding the molecular mechanisms underlying sickle cell disease pain, with preliminary data suggesting that inhibition of LPA synthesis and LPA receptor signaling can reduce hyperalgesia. This basic science research aligns with NHLBI's mandate to fund hypothesis-driven mechanistic research across the cardiovascular and hematologic disease spectrum and will contribute to understanding pathways that may inform therapeutic interventions for the severe, debilitating pain experienced by the approximately 6 million individuals affected by sickle cell disease globally.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $747.0k | 7/7/26 |