Project Grant R01HL180880
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $158,652 project grant under CFDA 93.837 - Cardiovascular Diseases Research to Duke University. The grant, awarded on September 1, 2025, will fund research on the impact of alveolar macrophage senescence in aged donor lungs on outcomes following lung transplantation. The project aims to investigate the underlying mechanisms driving the poorer long-term outcomes observed when using lungs...
- This federal Project Grant award, valued at $174,420.00, was granted by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award will support research by the University of Pennsylvania to investigate the impact of ongoing centralization of deceased organ donor management on lung transplantation outcomes. The study aims to analyze the effects of transferring deceased donors from hospitals to specialized regional Donor Care...
- The University of Utah was awarded a $782,289 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on August 15, 2025. The grant supports a study to incorporate donor lung CT images into machine learning models to predict the risk of severe primary graft dysfunction (PGD) after lung transplantation. The research aims to improve the prediction of PGD, a leading cause of morbidity and mortality in the first 30 days post-transplant, by...
- This federal Project Grant award of $700,857 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to study the effects of truncal adiposity (obesity) on lung collapse and severity in patients with acute hypoxemic respiratory failure (AHRF). The research team at the Massachusetts General Hospital will use advanced imaging techniques, including computed tomography (CT) scans, to quantify how the distribution and magnitude of...
- The National Heart Lung and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $775,992 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to the University of North Carolina at Chapel Hill (UNC-CH). The grant, with a project period from February 1, 2025 to November 30, 2029, will fund research to investigate the role of glucocorticoid signaling through regulatory T cells (Tregs) in the resolution of acute lung injury and acute respiratory...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $750,162 to The Children's Hospital of Philadelphia (CHOP) to conduct research aimed at understanding the role of lymphatic dysfunction in the development of post-lung transplant bronchiolitis obliterans syndrome (BOS), a serious complication. The research project will use murine models to investigate the mechanisms of lymphatic vascular function after...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $147,486 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The project, titled "Identifying Inflammatory Signals Facilitating Ectopic KRT5+ Cell Migration and Their Function in the Alveoli", aims to investigate the mechanisms by which certain lung cells (KRT5+ cells)...
- This Project Grant award of $879,567 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the "Lung Injury in Oncologic Stem Cell Transplants (LIONS)" research project at The Children's Hospital of Philadelphia. The research aims to investigate the molecular mechanisms contributing to the development of lung injury, a major complication affecting up to 40% of pediatric hematopoietic cell transplant recipients. The research will...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $144,989 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop, train, and test deep generative models using computed tomography (CT) images to predict lung injury progression and treatment responses in patients with acute respiratory distress syndrome (ARDS). The goal is to leverage artificial intelligence and image...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $169,020 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Pennsylvania. The grant supports a 5-year research project to study how endothelial cells in the lungs coordinate immune responses after influenza infection and how a novel population of injury-associated capillary endothelial cells is regulated at sites of persistent lung injury. The project aims to gain a better...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $833,388 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to The Trustees of the University of Pennsylvania to conduct research on "Advanced Body Composition Imaging to Improve Outcomes in Lung Transplantation." The 5-year grant, awarded on August 25, 2025, will fund research to better quantify obesity-related risk factors for patients undergoing lung transplantation, with the goal of improving waitlist selection and operative management to increase pre- and post-transplant survival rates. The research will utilize computed tomography (CT) imaging to measure adipose (fat) distribution as a more accurate predictor of risk beyond just body mass index, to help ensure that high-risk candidates are waitlisted appropriately and receive surgical interventions tailored to minimize post-transplant complications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $833.4k | 8/21/25 |