Project Grant R01HL180762
- The National Heart, Lung, and Blood Institute awarded New York University $836,736 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate endothelial mechanosensing of circulatory flow in health and disease. The project will examine how endothelial cells lining blood and lymphatic vessels respond to fluid flow forces, with focus on the roles of PLXND1 (a transmembrane semaphorin receptor) and KLF2 (a transcription factor) in endothelial responses to...
- The National Heart, Lung, and Blood Institute awarded the Trustees of Boston University $849,790 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to decode regulatory variants in cardiovascular disease through functional annotation of non-coding variants associated with CVD. The recipient will characterize non-coding regulatory variants and their mechanisms using high-throughput experimental approaches in human cardiomyocytes. Aim 1 encompasses biophysical...
- The National Heart, Lung, and Blood Institute awarded Yale University $838,491 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify novel gene variants that drive endothelial cell activation during atherosclerotic cardiovascular disease. The recipient will elucidate mechanisms by which gain-of-function defects in ZFYVE21, an endosome-associated protein highly expressed in endothelial cells, contribute to endothelial cell activation and exacerbate...
- The National Heart, Lung, and Blood Institute awarded the University of Arizona $108,950 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop nanoplatforms for co-delivery of drugs and genes to protect lung endothelium from neonatal and pediatric lung injury. The recipient will optimize nanoparticle formulations for stability, safety, and endothelial targeting in neonatal lungs, characterizing physicochemical properties that influence targeting...
- The National Heart, Lung, and Blood Institute awarded the University of Arizona $726,242 on August 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to characterize the cellular and molecular role of GATA4 in bicuspid aortic valve disease. The project, R01HL183091, runs through May 31, 2030, with place of performance in Tucson, Arizona. The award funds three research aims. Aim 1 comprehensively characterizes a GATA4S379G mouse model of bicuspid aortic valve disease,...
- The National Heart, Lung, and Blood Institute awarded New York University $1,692,126 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to dissect the molecular mechanisms and therapeutic potential of CHROMR, a long noncoding RNA upregulated in atherosclerotic cardiovascular disease. The research will map CHROMR-protein interfaces and design steric-blocking oligonucleotides to selectively disrupt the CHROMR-IRF2BP2 interaction, decoupling its pro-inflammatory...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $618,352 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the mechanical regulation of endothelial lipid droplet metabolism and its role in vascular dysfunction. The research examines how oscillatory shear stress suppresses triglyceride hydrolysis by inactivating the transcription factor FOXO1, leading to lipid droplet accumulation in...
- The National Heart, Lung, and Blood Institute awarded New York University $763,960 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the molecular mechanisms by which long non-coding RNA IRF1-AS1 and its mouse ortholog GM12216 regulate atherosclerotic cardiovascular disease. The research will examine how IRF1-AS1 coordinates expression of protein-coding genes including the transcriptional regulator IRF1 in myeloid cells to drive atherogenesis,...
- The National Heart, Lung, and Blood Institute awarded the University of Arizona $748,677 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop nanoparticle delivery systems targeting lung endothelial cell repair in pediatric acute respiratory distress syndrome (ARDS). The research addresses the lack of innovative molecular approaches to pediatric ARDS management by engineering lung endothelial cell-specific nanoparticle carriers capable of delivering...
- The National Heart, Lung, and Blood Institute awarded the University of California, Los Angeles $1.368 million on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanosensitive signaling mechanisms that support endothelial cell resilience in the context of cardiovascular disease treatment. The research elucidates a mechanosensitive signaling domain in endothelial cells and tests how TRPV4-mediated calcium signaling promotes vascular resilience....
The National Heart, Lung, and Blood Institute awarded the University of Arizona $778,582 on August 15, 2026, to identify genetic variants that perturb gene regulatory responses to athero-protective and athero-prone hemodynamic waveforms in human endothelial cells. The award funds research under the Cardiovascular Diseases Research program (CFDA 93.837). The project investigates how natural genetic variation governs endothelial cell responses to hemodynamic shear stress from blood flow, with the goal of developing new biomarkers, risk prediction methods, and intervention strategies for cardiovascular disease. Current understanding of CVD focuses primarily on cholesterol-lowering treatments despite genetic studies showing that cholesterol explains only a fraction of CVD risk; this award targets unexplored pathways involving the protective or harmful effects of blood flow patterns on artery walls. The work comprises three specific aims: identifying non-coding regulatory elements whose flow responses are genetically variable, characterizing how genetic variation modulates target gene expression in endothelial cells under different hemodynamic conditions, and validating findings to explain heritability of vascular diseases. Performance occurs in Tucson, Arizona, with a period of performance through April 30, 2030. The award is a Project Grant, an assistance type under the NHLBI's competitive research funding mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $778.6k | 8/12/26 |