Project Grant R01HL179230
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $756,228 project grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Florida (UF) to develop an AI-enabled model to better predict outcomes for patients with chronic limb-threatening ischemia (CLTI) who undergo revascularization procedures. The project aims to supplement electronic health record and clinical notes data with prospectively collected...
- The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $159,980 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) for the period of March 1, 2025 to August 31, 2026. The grant will fund research to investigate the role of the protein Klotho in the pathogenesis of medial arterial calcification, which is a major risk factor for limb amputation in patients with peripheral artery disease...
- The University of North Carolina at Chapel Hill (UNC-CH) was awarded a $767,077 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to validate and extend a platform technology for the delivery of protein-based drugs, including application to thrombolytic therapeutics. The proposed research aims to address key technical challenges such as accommodating a range of thrombolytic proteins, achieving multi-drug synergism, improving...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $410,449 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The Leland Stanford Junior University (Stanford University) on August 1, 2025. The funding supports research to develop novel synthetic biology strategies that would enable the quantitative and dynamic regulation of growth factors and cytokines produced from human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs). The goal...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $763,858 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System Inc.) to assess the impact of improving cardiovascular disease (CVD) care for adults with diagnosed diabetes across diverse global settings. The project, led by Dr. Jennifer Manne-Goehler and an interdisciplinary team, aims to develop the PREDICT-DM global...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,372,795 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Washington. The grant, effective January 15, 2025 through December 31, 2027, will provide infrastructure support to maintain the Cardiovascular Health Study (CHS) coordinating center, databases, and activities, including support for 78 ancillary studies. It will also assist investigators in developing new ancillary studies,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $425,505 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Louisiana State University Health Sciences Center-Shreveport (LSU Health Sciences Center-Shreveport) to investigate the role of cell-specific Programmed Death-Ligand 1 (PD-L1) in cardiac pathophysiology following ischemic injury and cancer. The project aims to elucidate the specific mechanisms by which fibroblast-specific and myeloid...
- The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $169,992 Project Grant to the University of Colorado-Denver on September 18, 2025. The grant will fund a 5-year mixed methods study to inform initial antihypertensive prescribing and develop a patient self-titration intervention. The study aims to understand barriers and facilitators to initiating antihypertensive combination therapy versus stepped...
- This federal Project Grant award of $761,028 from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 Cardiovascular Diseases Research will support a multi-site prospective study on hypoxemia during sleep in adults with sickle cell anemia (SCA). The study aims to examine the prevalence, clinical impact, and response to treatment of sleep-related hypoxemia in this patient population across four institutions, including both urban and rural sites. Key activities will involve...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $699,296 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of North Carolina at Chapel Hill (UNC-CH) to investigate optimal treatment strategies for patients with chronic limb threatening ischemia (CLTI). The proposed research will leverage data from the NHLBI-sponsored BEST-CLI randomized controlled trial to identify patient characteristics associated with different disease trajectories and treatment patterns after initial revascularization. It will also measure the effect of partial adherence to clinical follow-up visits on CLTI-free survival. The findings aim to define key decision points for customizing CLTI treatment to improve clinical outcomes. The award has an ultimate completion date of May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $699.3k | 8/7/25 |